Undulatoside A
Undulatoside A has anti-inflammatory activity, it exhibits inhibition on nitric oxide production in lipopolysaccharide induced RAW 264.7 macrophages with the IC50 value of 49.8 uM.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ACS Pharmacol.Transl.Sci.2024, 4c00003.
Int J Mol Sci.2022, 23(5):2796.
Korean J. Medicinal Crop Sci.2022, 30(2):117-123.
J Biol Chem.2021, 297(6):101362.
Herbal Formula Science2024, 32(2):155-179.
Molecules.2019, 25(1):E103
Br J Pharmacol.2020, 10.1111
Cell Signal.2024, 124:111467.
Food and Bioprocess Technology2017, 10(6):1074-1092
Front Pharmacol.2022, 13:883475.
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J Asian Nat Prod Res. 2016;18(1):59-64.
Two new glycosides from Dryopteris fragrans with anti-inflammatory activities.[Pubmed:
26700189]
METHODS AND RESULTS:
Phytochemical investigation on the aqueous extract from Dryopteris fragrans led to the isolation of one new chromone glycoside, frachromone C (1), and one new coumarin glycoside, dryofracoulin A (2), together with one known Undulatoside A (3). Their structures were elucidated by a combination of 1D and 2D NMR, HRMS, and chemical analysis.
CONCLUSIONS:
Compounds 1-3 exhibited inhibition on nitric oxide production in lipopolysaccharide induced RAW 264.7 macrophages with their IC50 values of 45.8, 65.8, and 49.8 μM, respectively.
Bioorg Med Chem Lett. 2012 Oct 1;22(19):6267-71.
Anti-adipogenic chromone glycosides from Cnidium monnieri fruits in 3T3-L1 cells.[Pubmed:
22932311]
METHODS AND RESULTS:
Seven new chromone glycosides, monnierisides A (3), B (10), C (11), D (12), E (13), F (15) and G (16) were isolated from Cnidium. monnieri, together with ten known chromone derivatives, Undulatoside A (1), cnidimol C (2), saikochromoside A (4), cnidimoside A (5), cnidimoside B (6), 2-methyl-5-hydroxy-6-(2-butenyl-3-hydroxymethyl)-7-(β-d-glucopyranosyloxy)-4H-1-benzopyran-4-one (7), cnidimol D (8), hydroxycnidimoside A (9), umtatin (14) and 6'-hydroxylangelicain (17). The structures of isolated compounds were determined on the basis of spectroscopic analysis including 1D, 2D NMR and HR-MS.
CONCLUSIONS:
Among the compounds isolated, compounds 5, 6, 9 and 10 significantly inhibited adipocyte differentiation as measured by fat accumulation in 3T3-L1 cells using Oil Red O staining.
J Asian Nat Prod Res. 2006 Oct-Nov;8(7):663-70.
Chromone glycosides from Knoxia corymbosa.[Pubmed:
17135054]
METHODS AND RESULTS:
Four new chromone glycosides, corymbosins K1-K4 (3-6), together with two known compounds, noreugenin (1) and Undulatoside A (2), were isolated from the whole plant of Knoxiacorymbosa (Rubiaceae).
CONCLUSIONS:
The structures of the new compounds were established through extensive NMR or X-ray spectroscopic analysis as 7-O-beta-D-allopyranosyl-5-hydroxy-2-methylchromone (corymbosin K1, 3), 7-O-beta-D-6-acetylglucopyranosyl-5-hydroxy-2-methylchromone (corymbosin K2, 4), 7-O-[6-O-(4-O-trans-caffeoyl-beta-D-allopyranosyl)]-beta-D-glucopyranosyl-5-hydroxy-2-methylchromone (corymbosin K3, 5) and 7-O-[6-O-(4-O-trans-feruloyl-beta-D-allopyranosyl)]-beta-D-glucopyranosyl-5-hydroxy-2- methylchromone (corymbosin K4, 6). Compounds 2-5 were subjected to test their immunomodulatory activity in vitro.
