dl-Aloesol
dl-Aloesol is a natural product from the secondary metabolites of endophytic fungus HCCB06030.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Research Square2021, March 3rd.
Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
Front Microbiol.2022, 12:833233.
Food Science and Human Wellness2022, 11(4):965-974
Chem Biodivers.2023, 20(10):e202300741.
ScientificWorldJournal.2022, 2022:4806889.
Food Chemistry: X.2022, 2022.100270
Agronomy2023, 13(9), 2410.
Plant Direct.2021, 5(12):e372.
Metabolites.2020, 11(1):E11.
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Chem Pharm Bull (Tokyo). 1991 Mar;39(3):704-8.
Metabolism of aloesin and related compounds by human intestinal bacteria: a bacterial cleavage of the C-glucosyl bond and the subsequent reduction of the acetonyl side chain.[Pubmed:
2070451]
METHODS AND RESULTS:
By anaerobic incubation with a bacterial mixture from human feces, aloesin (aloeresin B; 1) was converted to 2-acetonyl-7-hydroxy-5-methylchromone (aloesone; 3) and dl-7-hydroxy-2-(2'-hydroxypropyl)-5-methylchromone (aloesol; 4a + 4b) through a cleavage of the C-glucosyl bond, followed by reduction of the acetonyl side chain. An analogous compound, aloeresin A (2), was converted to p-coumaric acid and aloesin (1), the latter being subsequently transformed to aloesone (3) and dl-Aloesol (4a + 4b). On the other hand, 7-O-methylated derivatives (7, 5a and 5b) of aloesin and of 8-C-glucosylaloesol were not cleaved to the corresponding aglycones, suggesting the importance of a free hydroxy group adjacent to the C-glucosyl group in the molecule for the bacterial cleavage of aloesin derivatives.
CONCLUSIONS:
This is the first report on the cleavage of the C-glycosyl bond of chromone C-glucosides by intestinal bacteria.
