Turmeronol A
Turmeronol A and turmeronol B are inhibitors of soybean lipoxygenase, they inhibited soybean lipoxygenase at the IC50 values of 16 uM and 9 uM, respectively.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Phytomedicine.2018, 38:45-56
Adv. Anim. Vet. Sci.2024, 12(5):986-993.
Vet World.2023, 16(3):618-630.
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Int J Mol Sci.2021, 22(16):8604.
National Natural Science Foundation of China2024, pages 33.
ACS Nano.2023, 17(11):9972-9986.
Biomed Pharmacother.2024, 176:116765.
Sichuan Agricultural University2023, 4630743.
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Agricultural & Biological Chemistry, 2006 , 54 (9) :2367-71.
Turmeronol A and turmeronol B, new inhibitors of soybean lipoxygenase[Reference:
WebLink]
METHODS AND RESULTS:
In the course of our screening program for inhibitors of soybean lipoxygenase, we isolated two new phenolic sesquiterpene ketones named Turmeronol A and turmeronol B from the spice turmeric (dried rhizome of Curucuma longa L.). Their structures were determined to be 2-methyl-6-(3-hydroxy-4-methylphenyl)-2-hepten-4-one and 2-methyl-6-(2-hydroxy-4-methylphenyl)-2-hepten-4-one, respectively.
CONCLUSIONS:
Turmeronol A and turmeronol B inhibited soybean lipoxygenase at the IC50 values of 16 µm and 9 µm, respectively. These compounds prevented the autoxidation of linoleic acid at a concentration of ca. 200 ppm.
Dhaka University Journal of Pharmaceutical Sciences, 2010, 8(1):39-45.
Phytochemical and Biological Investigations of Curcuma longa.[Reference:
WebLink]
METHODS AND RESULTS:
Seven compounds, Turmeronol A (1), turmeronol B (2), 3,4-dimethoxycinnamic acid (3), 4-hydroxy- 3-methoxycinnamic acid (4), 4-hydroxybenzaldehyde (5), 2,3,5,6-tetrahydroxyarturmerone (6) and 4-hydroxy- bisabola-2,10-diene-9-one (7) have been isolated from the carbon tetrachloride soluble fraction of a methanol extract of the rhizomes of Curcuma longa. Careful interpretation of the NMR data and comparison with Turmeronol A (1) allowed tentative identification of compound 6 as 2,3,5,6-tetrahydroxy-arturmerone, which appears to be a new molecule.
CONCLUSIONS:
The n-hexane, carbon tetrachloride and chloroform extractives of the rhizomes when subjected to antimicrobial screening and brine shrimp lethality bioassay demonstrated mild to moderate antimicrobial activity and strong cytotoxicity with LC50 value 1.56 μg/ml.
Yao Xue Xue Bao. 2008 Jul;43(7):724-7.
Alkaloid and sesquiterpenes from the root tuber of Curcuma longa.[Pubmed:
18819476]
METHODS AND RESULTS:
One new quinoline alkaloid and seven known bisabolane sesquiterpenes: 2-(2'-methyl-1'-propenyl)-4, 6-dimethyl-7-hydroxyquinoline (1), 2, 5-dihydroxybisabola-3, 10-diene (2), 4, 5-dihydroxybisabola-2,10-diene (3), Turmeronol A (4), bisacurone (5), bisacurone A (6), bisacurone B (7) , bisacurone C (8), as well as dehydrozingerone (9) and zingerone (10) were isolated from the root tuber of Curcuma longa. Their structures were identified by spectral evidence.
CONCLUSIONS:
Compound 1 is a new compound, compounds 6 -8 were isolated from this plant for the first time and compounds 9 - 10 from Curcuma for the first time.
