2-Deacetoxytaxinine B

2-Deacetoxytaxinine B
Product Name 2-Deacetoxytaxinine B
CAS No.: 191547-12-3
Catalog No.: CFN99887
Molecular Formula: C35H42O9
Molecular Weight: 606.7 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The barks of Taxus chinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
2-Deacetoxytaxinine B is a strongly inhibitor against U46619-induced aggregation, it shows strong inhibitory effects against arachidonic acid (AA)-induced aggregation.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Acta Agriculturae Scandinavica2015, 381-383
  • Pak J Pharm Sci.2023, 36(1):51-57.
  • Pharmacol Rep.2019, 71(2):289-298
  • Molecules.2023, 28(8):3376.
  • Drug Des Devel Ther.2020, 14:5189-5204.
  • Anticancer Res.2020, 40(10):5529-5538.
  • Molecules.2019, 24(17):E3127
  • Phytochem Anal.2016, 27(5):296-303
  • Research SPJ.2024, 0377.
  • Journal of Ginseng Research2023, 12.004.
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    Platelets are highly reactive components of the circulatory system. The cytoskeleton of a platelet is an important structure for platelet aggregation as stimulated by several agonists. An anticancer agent, taxol, has been suggested to exert platelet anti-aggregating activity by stabilizing microtubules during the aggregation process.
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    An activity-guided fractionation was performed with a methanol extract of the leaves and twigs of Taxus cuspidata to isolate taxanes with platelet anti-aggregating effects. Compounds 1 to 7 - taxinine (1), taxinine A (2), taxinine B (3), 2-Deacetoxytaxinine B (4), taxacin (5), taxchinin B (6), and taxol (7) - were obtained as the antiplatelet components of this plant. These taxane compounds present the possibility of securing new antiplatelet compounds which differ from currently available antiplatelet agents in chemical structure and possibly in mechanisms of action.
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