Streptozotocin

Streptozotocin
Product Name Streptozotocin
CAS No.: 18883-66-4
Catalog No.: CFN93213
Molecular Formula: C8H15N3O7
Molecular Weight: 265.22 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Powder
Targets: PARP
Source: From Stre.achromogenes Uar.128
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Streptozotocin, which produces diabetes mellitus in experimental animals, has been reported to reduce the level of NAD in pancreatic isletsand to inhibit islet synthesis of proinsulin.Streptozotocin can induce pancreatic insulitis, which is a new model of diabetes mellitus.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Nutrients.2017, 10(1)
  • Pharm Biol.2016, 54(7):1255-62
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • J Ethnopharmacol.2019, 244:112074
  • International. J. of Food Properties 2017, 20:S131-S140
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Food Research International2020, 108987
  • Nat Prod Sci.2014, 20(3):182-190
  • Phytomedicine.2019, 56:48-56
  • Phytother Res.2015, 29(7):1088-96
  • 5-Aza-2'-deoxycytidine

    Catalog No: CFN90007
    CAS No: 2353-33-5
    Price: $218/20mg
    Cytidine

    Catalog No: CFN92490
    CAS No: 65-46-3
    Price: $30/20mg
    Histamine

    Catalog No: CFN90029
    CAS No: 51-45-6
    Price: $30/20mg
    L-carnosine

    Catalog No: CFN93091
    CAS No: 305-84-0
    Price: $40/20mg
    2'',3''-Di-O-acetyl-5''-deoxy-5-fuluro-D-cytidine

    Catalog No: CFN90094
    CAS No: 161599-46-8
    Price: Inquiry(manager@chemfaces.com)
    5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate

    Catalog No: CFN90095
    CAS No: 162204-20-8
    Price: Inquiry(manager@chemfaces.com)
    Uracil

    Catalog No: CFN97132
    CAS No: 66-22-8
    Price: $70/1g
    Uridine

    Catalog No: CFN97000
    CAS No: 58-96-8
    Price: $30/20mg
    Thymidine

    Catalog No: CFN98806
    CAS No: 50-89-5
    Price: $30/20mg
    Allantoin

    Catalog No: CFN97557
    CAS No: 97-59-6
    Price: $30/20mg
    Nature, 1981, 294(5838):284-6.
    Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.[Pubmed: 6272129]
    Streptozotocin, which produces diabetes mellitus in experimental animals, has been reported to reduce the level of NAD in pancreatic isletsand to inhibit islet synthesis of proinsulin. The decrease in NAD is due to increased NAD degradation mediated by islet nuclear poly(ADP-ribose) synthetase. Evidence suggests that poly(ADP-ribose) synthetase is activated when DNA is fragmented.
    METHODS AND RESULTS:
    Here we describe that both Streptozotocin and alloxan, which also produces experimental diabetes mellitus, cause DNA strand breaks which stimulate nuclear poly(ADP-ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.
    Science, 1976, 193(4251):415-7.
    Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus.[Pubmed: 180605]

    METHODS AND RESULTS:
    Multiple small injections of Streptozotocin in mice produce pancreatic insulitis, with progression to nearly complete beta cell destruction and diabetes mellitus. The timing and appearance of the inflammatory islet lesions suggest but do not prove that Streptozotocin acts by initiating a cell-mediated immune reaction.
    CONCLUSIONS:
    Ultrastructural evidence of abundant type C viruses within beta cells of treated mice suggests that Streptozotocin may activate murine leukemia virus in vivo in susceptible hosts.
    Morusin

    Catalog No: CFN97083
    CAS No: 62596-29-6
    Price: $128/20mg
    Prunasin

    Catalog No: CFN97566
    CAS No: 99-18-3
    Price: $223/5mg
    Vicenin -2

    Catalog No: CFN92031
    CAS No: 23666-13-9
    Price: $188/10mg
    Norwogonin

    Catalog No: CFN92218
    CAS No: 4443-09-8
    Price: $388/10mg
    Methyl 5-O-feruloylquinate

    Catalog No: CFN92445
    CAS No: 154461-64-0
    Price: $516/5mg
    7-Hydroxyaristolochic acid A

    Catalog No: CFN90517
    CAS No: 79185-75-4
    Price: $220/5mg
    Mulberroside F

    Catalog No: CFN90794
    CAS No: 193483-95-3
    Price: $288/10mg
    Glicoricone

    Catalog No: CFN95063
    CAS No: 161099-37-2
    Price: $333/5mg
    Daidzein-4',7-diglucoside

    Catalog No: CFN95094
    CAS No: 53681-67-7
    Price: $288/10mg
    4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol

    Catalog No: CFN95200
    CAS No: 913643-31-9
    Price: $368/5mg