Sophorabioside

Sophorabioside
Product Name Sophorabioside
CAS No.: 2945-88-2
Catalog No.: CFN90958
Molecular Formula: C27H30O14
Molecular Weight: 578.52 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The seeds of Sophora japonica.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $288/10mg
Sophorabioside is a natural product from Sophora japonica.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Mol Pharm.2017, 14(9):3164-3177
  • J-STAGE2015, 249-255
  • Heliyon.2022, 8(12):e12031.
  • Front Cell Infect Microbiol.2018, 8:292
  • Antioxidants (Basel).2021, 10(3):379.
  • Int Immunopharmacol.2019, 71:22-31
  • Cancer Manag Res.2019, 11:483-500
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Food Science.2023, 4(20):268-282.
  • BMC Complement Med Ther. 2020, 20(1):91.
  • Sophoricoside

    Catalog No: CFN90148
    CAS No: 152-95-4
    Price: $40/20mg
    New compound 3

    Catalog No: CFN95184
    CAS No: N/A
    Price: $368/5mg
    Sophorabioside

    Catalog No: CFN90958
    CAS No: 2945-88-2
    Price: $288/10mg
    Genistein 7-O-beta-D-glucopyranoside-4'-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside]

    Catalog No: CFN95159
    CAS No: 70404-42-1
    Price: $318/10mg
    Genistin

    Catalog No: CFN90250
    CAS No: 529-59-9
    Price: $40/20mg
    Genistein 7-O-glucuronide

    Catalog No: CFN70353
    CAS No: 38482-81-4
    Price: Inquiry(manager@chemfaces.com)
    4''-methyloxy-Genistin

    Catalog No: CFN93006
    CAS No: 950910-16-4
    Price: Inquiry(manager@chemfaces.com)
    Ambocin

    Catalog No: CFN89471
    CAS No: 108044-05-9
    Price: $318/5mg
    New compound 4

    Catalog No: CFN95185
    CAS No: N/A
    Price: $368/5mg
    Lanceolarin

    Catalog No: CFN95166
    CAS No: 15914-68-8
    Price: $318/5mg
    PLoS One. 2014 Jun 3;9(6):e98559.
    Isolation of antiosteoporotic compounds from seeds of Sophora japonica.[Pubmed: 24892557]
    Chemical investigation of Sophora japonica seeds resulted in the isolation of seven metabolites identified as: genistin (1), sophoricoside (2), Sophorabioside (3), sophoraflavonoloside (4), genistein 7,4'-di-O-β-D-glucopyransoide (5), kaempferol 3-O-α-L-rhamnopyranosyl(1 → 6)β-D-glucopyranosyl(1 → 2)β-D-glucopyranoside (6) and rutin (7).
    METHODS AND RESULTS:
    Compounds 1, 2 and 5 showed significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range. Compounds 1 and 2 showed minimal cell membrane damaging effect using LDH leakage assay. Accordingly, compound 2 (sophoricoside, (SPH)) was selected for further in-vivo studies as a potential anti-osteoporosis agent. The anti-osteoporotic effect of SPH was assessed in ovarectomized (OVX) rats after oral administration (15 mg/kg and 30 mg/kg) for 45 days compared to estradiol (10 µg/kg) as a positive control. Only in a dose of 30 mg/kg, SPH regained the original mechanical bone hardness compared to normal non-osteoporotic group. However, SPH (15 mg/kg) significantly increased the level of alkaline phosphatase (ALP) to normal level. Treatment with SPH (30 mg/kg) increased the level of ALP to be higher than normal group. SPH (15 mg/kg) did not significantly increase the serum level of osteocalcin (OC) compared to OVX group. On the other hand, treatment with SPH (30 mg/kg) significantly increased the level of OC to 78% higher than normal non-ovarectomized animals group. In addition, SPH (15 mg/kg) decreased the bone resorption marker, acid phosphatase (ACP) to normal level and SPH (30 mg/kg) further diminished the level of serum ACP.
    CONCLUSIONS:
    Histopathologically, sophoricoside ameliorated the ovarectomy induced osteoporosis in a dose dependent manner. The drug showed thicker bony trabeculae, more osteoid, and more osteoblastic rimming compared to OVX group.
    Oleuroside

    Catalog No: CFN95099
    CAS No: 116383-31-4
    Price: $288/20mg
    (1,5E,11E)-tridecatriene-7,9-diyne-3,4-diacetate

    Catalog No: CFN95161
    CAS No: 201012-14-8
    Price: $318/10mg
    24-Hydroxymomordicine III

    Catalog No: CFN95169
    CAS No: N/A
    Price: $318/5mg
    Citrusin B

    Catalog No: CFN95178
    CAS No: 105279-10-5
    Price: $388/5mg
    N-Methylcorydalmine

    Catalog No: CFN95204
    CAS No: 81010-29-9
    Price: $398/5mg
    Isolappaol C

    Catalog No: CFN95225
    CAS No: 929905-15-7
    Price: $333/10mg
    15-Deoxypulic acid

    Catalog No: CFN95262
    CAS No: 95523-05-0
    Price: $368/5mg
    Sibiricose A4

    Catalog No: CFN95298
    CAS No: 241125-73-5
    Price: $318/5mg
    Isomargaritene

    Catalog No: CFN95304
    CAS No: 64271-11-0
    Price: $318/10mg
    Gynosaponin TN2

    Catalog No: CFN95331
    CAS No: 77658-95-8
    Price: $318/5mg