Sophorabioside

Sophorabioside
Product Name Sophorabioside
CAS No.: 2945-88-2
Catalog No.: CFN90958
Molecular Formula: C27H30O14
Molecular Weight: 578.52 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The seeds of Sophora japonica.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $288/10mg
Sophorabioside is a natural product from Sophora japonica.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Funct Foods2019, 54:449-456
  • Acta Pharmaceutica Hungarica2016, 86:35-40
  • Front Microbiol.2022, 13:835463.
  • ACS Nano.2018, 12(4):3385-3396
  • PLoS One.2017, 12(3):e0173585
  • Phytother Res.2019, 33(3):676-689
  • ACS Omega.2021, 6(36):23460-23474.
  • J Mol Med (Berl).2018, 96(7):661-672
  • Fitoterapia.2015, 100:179-86
  • Arch Pharm Res.2015, 38(6):1080-9
  • New compound 4

    Catalog No: CFN95185
    CAS No: N/A
    Price: $368/5mg
    Lanceolarin

    Catalog No: CFN95166
    CAS No: 15914-68-8
    Price: $318/5mg
    Sissotrin

    Catalog No: CFN97005
    CAS No: 5928-26-7
    Price: $268/5mg
    Genistein 7,4'-di-O-beta-D-glucopyranoside

    Catalog No: CFN90953
    CAS No: 36190-98-4
    Price: $268/20mg
    6''-O-Malonylgenistin

    Catalog No: CFN90631
    CAS No: 51011-05-3
    Price: $388/5mg
    Glycitin

    Catalog No: CFN99105
    CAS No: 40246-10-4
    Price: $70/20mg
    6''-O-Acetylglycitin

    Catalog No: CFN93455
    CAS No: 134859-96-4
    Price: Inquiry(manager@chemfaces.com)
    6''-O-xylosyl-glycitin

    Catalog No: CFN80151
    CAS No: 231288-18-9
    Price: Inquiry(manager@chemfaces.com)
    Odoratin-7-O-beta-D-glucopyranoside

    Catalog No: CFN91882
    CAS No: 210413-47-1
    Price: Inquiry(manager@chemfaces.com)
    Tectoridin

    Catalog No: CFN99921
    CAS No: 611-40-5
    Price: $68/20mg
    PLoS One. 2014 Jun 3;9(6):e98559.
    Isolation of antiosteoporotic compounds from seeds of Sophora japonica.[Pubmed: 24892557]
    Chemical investigation of Sophora japonica seeds resulted in the isolation of seven metabolites identified as: genistin (1), sophoricoside (2), Sophorabioside (3), sophoraflavonoloside (4), genistein 7,4'-di-O-β-D-glucopyransoide (5), kaempferol 3-O-α-L-rhamnopyranosyl(1 → 6)β-D-glucopyranosyl(1 → 2)β-D-glucopyranoside (6) and rutin (7).
    METHODS AND RESULTS:
    Compounds 1, 2 and 5 showed significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range. Compounds 1 and 2 showed minimal cell membrane damaging effect using LDH leakage assay. Accordingly, compound 2 (sophoricoside, (SPH)) was selected for further in-vivo studies as a potential anti-osteoporosis agent. The anti-osteoporotic effect of SPH was assessed in ovarectomized (OVX) rats after oral administration (15 mg/kg and 30 mg/kg) for 45 days compared to estradiol (10 µg/kg) as a positive control. Only in a dose of 30 mg/kg, SPH regained the original mechanical bone hardness compared to normal non-osteoporotic group. However, SPH (15 mg/kg) significantly increased the level of alkaline phosphatase (ALP) to normal level. Treatment with SPH (30 mg/kg) increased the level of ALP to be higher than normal group. SPH (15 mg/kg) did not significantly increase the serum level of osteocalcin (OC) compared to OVX group. On the other hand, treatment with SPH (30 mg/kg) significantly increased the level of OC to 78% higher than normal non-ovarectomized animals group. In addition, SPH (15 mg/kg) decreased the bone resorption marker, acid phosphatase (ACP) to normal level and SPH (30 mg/kg) further diminished the level of serum ACP.
    CONCLUSIONS:
    Histopathologically, sophoricoside ameliorated the ovarectomy induced osteoporosis in a dose dependent manner. The drug showed thicker bony trabeculae, more osteoid, and more osteoblastic rimming compared to OVX group.
    Gymnoside III

    Catalog No: CFN95033
    CAS No: 899430-03-6
    Price: $318/10mg
    1,3,6-Tri-O-galloylglucose

    Catalog No: CFN95043
    CAS No: 18483-17-5
    Price: $318/10mg
    Carasinol D

    Catalog No: CFN95044
    CAS No: 1072797-66-0
    Price: $333/5mg
    Poricoic acid B

    Catalog No: CFN95050
    CAS No: 137551-39-4
    Price: $318/20mg
    New Compound 1

    Catalog No: CFN95152
    CAS No: N/A
    Price: $398/5mg
    2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one

    Catalog No: CFN95197
    CAS No: 1809980-25-3
    Price: $318/10mg
    New compound 11

    Catalog No: CFN95351
    CAS No: N/A
    Price: $318/10mg
    Yinxiancaoside C

    Catalog No: CFN95377
    CAS No: 1159908-74-3
    Price: $413/5mg
    Methylpicraquassioside B

    Catalog No: CFN95379
    CAS No: 1443757-89-8
    Price: $318/10mg
    3'-Hydroxy-5,7,4'-trimethoxyflavone

    Catalog No: CFN95396
    CAS No: 33554-52-8
    Price: $318/5mg