Scutebarbatine W

Scutebarbatine W
Product Name Scutebarbatine W
CAS No.: 1312716-25-8
Catalog No.: CFN96705
Molecular Formula: C33H37NO8
Molecular Weight: 575.65 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Targets: NO
Source: The whole plants of Scutellaria barbata.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Scutebarbatine W can inhibit nitric oxide production efficiently with IC50 values of lower than 50 uM, it may have potential effects on the reduction of neuroinflammation.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Chem. Biodivers.,2017 Aug 14.
    Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-stimulated Microglial Cells.[Pubmed: 28805952]

    METHODS AND RESULTS:
    The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as Scutebarbatine W (2), scutebatas B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-nicotinolylscutebarbatine G (7) and Scutebarbatine X (8) were isolated. The structures of these compounds were elucidated based on NMR and MS data, and the comparison of literature values.
    CONCLUSIONS:
    All the compounds except compound 7 inhibited NO production efficiently with IC50 values of lower than 50 μM. Particularly, compound 1 and 8 were the most efficient with IC50 values of 25.8 and 27.4 μM, respectively. This is the first report suggesting the potential of S. barbata on the reduction of neuroinflammation.
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