Monomethyl kolavate

Monomethyl kolavate
Product Name Monomethyl kolavate
CAS No.: 24513-41-5
Catalog No.: CFN98262
Molecular Formula: C21H32O4
Molecular Weight: 348.5 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Targets: Antifection
Source: The woods of Gossweilerodendron balsamiferum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Monomethyl kolavate is a power Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) inhibitor, with an IC50 value of 12uM.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Oncology Letters2018, 4690-4696
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • Natural Product Communications2020, doi: 10.1177.
  • Industrial Crops and Products2023, 199:116746.
  • Phytomedicine.2018, 40:37-47
  • Antimicrob Agents Chemother.2020, AAC.01921-20.
  • University of Guelph2021, 12.
  • BMC Plant Biol.2022, 22(1):128.
  • Nutrients.2023, 15(24):5020.
  • Oncotarget.2017, 8(53):90925-90947
  • Scutebata G

    Catalog No: CFN99327
    CAS No: 1207181-63-2
    Price: Inquiry(manager@chemfaces.com)
    6-O-Nicotinoylscutebarbatine G

    Catalog No: CFN96994
    CAS No: 1206805-30-2
    Price: Inquiry(manager@chemfaces.com)
    Scutebarbatine W

    Catalog No: CFN96705
    CAS No: 1312716-25-8
    Price: Inquiry(manager@chemfaces.com)
    2-Oxokolavelool

    Catalog No: CFN97783
    CAS No: 221466-41-7
    Price: Inquiry(manager@chemfaces.com)
    Kolavenol

    Catalog No: CFN97792
    CAS No: 19941-83-4
    Price: Inquiry(manager@chemfaces.com)
    2-Oxokolavenol

    Catalog No: CFN97832
    CAS No: 130395-82-3
    Price: Inquiry(manager@chemfaces.com)
    16-Oxocleroda-3,13E-dien-15-oic acid

    Catalog No: CFN96984
    CAS No: 117620-72-1
    Price: Inquiry(manager@chemfaces.com)
    Monomethyl kolavate

    Catalog No: CFN98262
    CAS No: 24513-41-5
    Price: Inquiry(manager@chemfaces.com)
    Scutebata E

    Catalog No: CFN99325
    CAS No: 1207181-61-0
    Price: Inquiry(manager@chemfaces.com)
    Scutebata F

    Catalog No: CFN99326
    CAS No: 1207181-62-1
    Price: Inquiry(manager@chemfaces.com)
    Molecules. 2015 Sep 3;20(9):16154-69.
    In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase.[Pubmed: 26404225 ]
    As part of our ongoing efforts to identify natural products with activity against pathogens causing neglected tropical diseases, we are currently performing an extensive screening of natural product (NP) databases against a multitude of protozoan parasite proteins.
    METHODS AND RESULTS:
    Within this project, we screened a database of NPs from a commercial supplier, AnalytiCon Discovery (Potsdam, Germany), against Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH), a glycolytic enzyme whose inhibition deprives the parasite of energy supply. NPs acting as potential inhibitors of the mentioned enzyme were identified using a pharmacophore-based virtual screening and subsequent docking of the identified hits into the active site of interest. In a set of 700 structures chosen for the screening, 13 (1.9%) were predicted to possess significant affinity towards the enzyme and were therefore tested in an in vitro enzyme assay using recombinant TbGAPDH. Nine of these in silico hits (69%) showed significant inhibitory activity at 50 µM, of which two geranylated benzophenone derivatives proved to be particularly active with IC50 values below 10 µM.
    CONCLUSIONS:
    These compounds also showed moderate in vitro activity against T. brucei rhodesiense and may thus represent interesting starting points for further optimization.
    Naringin 4'-glucoside

    Catalog No: CFN95014
    CAS No: 17257-21-5
    Price: $338/5mg
    Tectoruside

    Catalog No: CFN95051
    CAS No: 38784-73-5
    Price: $288/20mg
    Shancigusin I

    Catalog No: CFN95061
    CAS No: 1435488-35-9
    Price: Inquiry(manager@chemfaces.com)
    Magnaldehyde B

    Catalog No: CFN95075
    CAS No: 92829-72-6
    Price: $318/5mg
    Scutellarein-7-O-glucoside

    Catalog No: CFN95082
    CAS No: 26046-94-6
    Price: $318/10mg
    6''-O-acetylsaikosaponin A

    Catalog No: CFN95086
    CAS No: 64340-46-1
    Price: $268/10mg
    1,2-Epoxy-10(14)-furanogermacren-6-one

    Catalog No: CFN95214
    CAS No: 383368-24-9
    Price: $318/10mg
    4-Methoxybenzoylacetic acid

    Catalog No: CFN95446
    CAS No: 13422-77-0
    Price: $318/5mg
    Ephedrannin D1

    Catalog No: CFN95547
    CAS No: 1592431-55-4
    Price: $318/5mg
    Methyl ganoderate F

    Catalog No: CFN95584
    CAS No: 98665-08-8
    Price: $368/5mg