Kolavenol

Kolavenol
Product Name Kolavenol
CAS No.: 19941-83-4
Catalog No.: CFN97792
Molecular Formula: C20H34O
Molecular Weight: 290.49 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Targets: Antifection
Source: The herbs of Eupatorium adenophora
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Kolavenol shows a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • BMC Complement Altern Med.2019, 19(1):11
  • Sichuan Agricultural University2023, 4630743.
  • Int J Mol Sci.2017, 18(12)
  • Front Immunol. 2020, 11:62.
  • ACS Omega.2021, 6(36):23460-23474.
  • ACS Synth Biol.2022, doi: 10.1021.
  • Environ Toxicol.2021, 36(9):1848-1856.
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • Bioorg Med Chem.2020, 28(12):115553.
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    J Ethnopharmacol. 1998 Jul;61(3):179-83.
    Bioassay-guided isolation of a diastereoisomer of kolavenol from Entada abyssinica active on Trypanosoma brucei rhodesiense.[Pubmed: 9705008 ]

    METHODS AND RESULTS:
    Bioassay-guided fractionation of the dichloromethane rootbark extract of Entada abyssinica (Leguminosae), a plant used by traditional healers in Uganda for the treatment of sleeping sickness, led to the isolation of a diastereoisomer of the clerodane type diterpene Kolavenol.
    CONCLUSIONS:
    This is the first report on this compound. It showed a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis.
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