Saikosaponin B4
Saikosaponin B4 can selectively inhibit ACTH-induced lipolysis.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion.[Pubmed:
25486247]
METHODS AND RESULTS:
Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponin B3 (1); Saikosaponin B4 (2); and saikosaponin D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC50 values of 1.8, 3.0 and 4.3 μM, respectively. Also, the aglycone structure 4 of compound 3 showed moderate inhibitory activity on L-selectin-mediated cell adhesion.
CONCLUSIONS:
From these results, we suspect that compound 3 isolated from Bupleurum falcatum roots would be a good candidate for therapeutic strategies to treat inflammation.
Chemical & Pharmaceutical Bulletin, 1980, 28(6):1788-1794.
Effects of saikosaponins on the metabolic actions of adrenaline, ACTH and insulin on the fat cells.[Reference:
WebLink]
METHODS AND RESULTS:
Saikosaponins a and d inhibited adrenaline-induced lipolysis in fat cells isolated from epididymal adipose tissue of rats. Saikosaponin a, Saikosaponin b1, Saikosaponin b2, Saikosaponin B4, Saikosaponin c and Saikosaponin d inhibited ACTH-induced lipolysis in the fat cells. Insulin-stimulated lipogenesis in adipose tissue was significantly reduced by saikosaponin d.
CONCLUSIONS:
Propranolol (a β-blocker) inhibited not only lipolytic actions induced by adrenaline and ACTH but also lipogenesis stimulated by insulin. In contrast to propranolol, saikosaponins b1, b2, b4 and c selectively inhibited ACTH-induced lipolysis without affecting the lipogenetic effect of insulin. The structure-activity relationship of saikosaponins is discussed.
