Platycodigenin
Platycodigenin has in vitro anti-proliferative activity against the HSC-T6 cell line.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
iScience.2020, 23(2):100849.
Anal Bioanal Chem.2023, 415(9):1641-1655.
J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
Eur Endod J.2020, 5(1):23-27.
Chinese Pharmacological Bulletin2019, 35(8):1120-1125
Int J Mol Sci.2022, 23(5):2796.
Separations2023, 10(11), 567;
Nat Prod Sci.2014, 20(3):182-190
Pharmaceutics.2021, 13(7):1028.
Wageningen University & Research2018, January 2018
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Molecules. 2012 Dec 13;17(12):14899-907.
Two new oleanane-type triterpenoids from Platycodi Radix and anti-proliferative activity in HSC-T6 cells.[Pubmed:
23519261]
Two new oleanane-type triterpenoids, named platycodonoids A and B (1, 2), together with five known saponins, including platycodin D (3), deapioplatycodin D (4), 3-O-β-D-glucopyranosyl polygalacic acid (5), 3-O-β-D-glucopyranosyl Platycodigenin (6) and polygalacin D (7), were isolated from the roots of Platycodon grandiflorum.
METHODS AND RESULTS:
On the basis of spectral data and chemical evidence, the structures of the new compounds were elucidated as 2β,3β,23,24-tetrahydroxy-28-nor-olean-12-en-16-one (1) and 2β,3β,23,24- tetrahydroxy-28-nor-olean-12-en-16-one-3-O-β-D-glucopyranoside (2). Compounds 1-7 were evaluated for their in vitro anti-proliferative activity against the HSC-T6 cell line.
