Picrinine
Picrinine has notable antitussive, antiasthmatic, expectorant, antiinflammatory and analgesic effects; medicinal composition containing picrinine as active ingredient can be prepared into multiple dosage forms and can be used for treating cold, fever, and respiratory disease caused by fever with good therapeutic effect, convenient application and high safety; picrinine can be used as quality index for pharmic control in preparing medicine for treating cold, fever and respiratory disease caused by fever.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Org Chem. 2015 Jul 13.
Fischer Indolizations as a Strategic Platform for the Total Synthesis of Picrinine.[Pubmed:
26134260]
Picrinine, which is a member of the akuammiline family of alkaloids, was first isolated in 1965 from the leaves of Alstonia scholaris. The natural product possesses a daunting polycyclic skeleton that contains a furanoindoline, a bridged [3.3.1]azabicycle, two N,O-acetal linkages, and six stereogenic centers. These structural features render Picrinine a challenging and attractive target for total synthesis.
METHODS AND RESULTS:
This paper provides a full account of our synthetic forays toward Picrinine, which culminates in the first total synthesis of this long-standing target. Central to the success of our approach is the use of the Fischer indolization reaction to introduce the C7 quaternary stereocenter and the indoline nucleus of the natural product's scaffold. We probe some of the subtleties of this classic transformation by examining some of the most complex Fischer indolization substrates to date. Additionally, we describe various roadblocks encountered in our experimental efforts, which were successfully overcome to complete the total synthesis of Picrinine.
Other References Information
J Am Chem Soc. 2014 Mar 26;136(12):4504-7.
Total synthesis of the akuammiline alkaloid picrinine.[Pubmed:
24597784 ]
We report the first total synthesis of the complex akuammiline alkaloid Picrinine, which was first isolated nearly five decades ago. Our synthetic approach features a concise assembly of the [3.3.1]-azabicyclic core, a key Fischer indolization reaction to forge the natural product's carbon framework, and a series of delicate late-stage transformations to complete the synthesis. Our synthesis of Picrinine also constitutes a formal synthesis of the related polycyclic alkaloid strictamine.
CN 101084894 B[P]. 2011.
Medicine for treating diseases concerned with respiratory and use thereof[Reference:
WebLink]
The invention discloses Picrinine (indoles) isolated from Alstonia scholaris. Picrinine has notable antitussive, antiasthmatic, expectorant, antiinflammatory and analgesic effects. Medicinal composition containing Picrinine as active ingredient can be prepared into multiple dosage forms and can be used for treating cold, fever, and respiratory disease caused by fever with good therapeutic effect, convenient application and high safety. Picrinine can be used as quality index for pharmic control in preparing medicine for treating cold, fever and respiratory disease caused by fever.
