Picrasin B
Picrasin B shows a significant clastogenic activity in cell cultures of Don lung cells of Chinese hamster.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Ethnopharmacol. 2009 Oct 29;126(1):114-8.
Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity.[Pubmed:
19665539]
Our objective was to assess whether it could be contemplated to recommend Quassia amara young leaf tea for treatment against malaria, and if yes, set up a standard protocol for preparing the herbal tea.
METHODS AND RESULTS:
The leaf tea was extracted with methylene chloride and the organic extract was fractionated with HPLC. Pure compounds were characterized and their in vitro cytotoxicity and antiplasmodial activity was determined.
We discovered that antimalarial Quassia amara young leaf tea contains several quassinoids: simalikalactone D (SkD, 1), Picrasin B (2), picrasin H (3), neoquassin (4), quassin (5), picrasin I (6) and picrasin J (7). These last two compounds are new. In addition, our experiments demonstrate that both biological activity and cytotoxicity of the remedy may be attributed solely to the presence of SkD.
CONCLUSIONS:
In conclusion, this preparation should not be recommended for treatment of malaria until a clinical study in humans is performed with SkD.
Chem. Lett.,1982(9):1425-6.
Picrasinoside-A,a novel quassinoid glucoside from Picrasma ailanthoides Planchon[Reference:
WebLink]
METHODS AND RESULTS:
A novel quassinoid glucoside picrasinoside-A was isolated from PLANCHON and the structure was established from spectral data, chemical transformations into Picrasin B and quassin, and enzyme hydrolysis.
CONCLUSIONS:
The aglycon Picrasin B showed a significant clastogenic activity in cell cultures of Don lung cells of Chinese hamster.
