Physcion 8-O-beta-D-monoglucoside

Physcion 8-O-beta-D-monoglucoside
Product Name Physcion 8-O-beta-D-monoglucoside
CAS No.: 23451-01-6
Catalog No.: CFN80399
Molecular Formula: C22H22O10
Molecular Weight: 446.4 g/mol
Purity: >=98%
Type of Compound: Anthraquinones
Physical Desc.: Powder
Targets: TNF-α
Source: The roots and rhizomes of Rheum palmatum L
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Physcion 8-O-beta-D-monoglucoside has anti-inflammatory activity, it can inhibit TNF-α-induced cytotoxicity and apoptosis in L929 cells via TNF-R1.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Breast Cancer2015 Jun;18(2):112-118.
  • Proc Natl Acad Sci U S A. 2016 Jul 26;
  • J Nat Prod. 2017 Apr 28;
  • Pharm Biol. 2017 Dec;
  • PLoS One. 2017 Mar 9;
  • Food Research InternationalApr. 2018;
  • Free Radic Biol Med.2016 Jun 25;97:307-319.
  • Invest New Drugs. 2017 Apr;
  • Molecules 2016, 21(6)2016 Jun 22;21(6).
  • BMC Complement Altern Med.2014 Sep 23;14:352.
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    Anal Bioanal Chem. 2016 Jul;408(19):5359-67.
    Identification of a ligand for tumor necrosis factor receptor from Chinese herbs by combination of surface plasmon resonance biosensor and UPLC-MS.[Pubmed: 27225174]
    Identification of bioactive compounds directly from complex herbal extracts is a key issue in the study of Chinese herbs.
    METHODS AND RESULTS:
    The present study describes the establishment and application of a sensitive, efficient, and convenient method based on surface plasmon resonance (SPR) biosensors for screening active ingredients targeting tumor necrosis factor receptor type 1 (TNF-R1) from Chinese herbs. Concentration-adjusted herbal extracts were subjected to SPR binding assay, and a remarkable response signal was observed in Rheum officinale extract. Then, the TNF-R1-bound ingredients were recovered, enriched, and analyzed by UPLC-QTOF/MS. As a result, Physcion 8-O-beta-D-monoglucoside (PMG) was identified as a bioactive compound, and the affinity constant of PMG to TNF-R1 was determined by SPR affinity analysis (K D  = 376 nM). Pharmacological assays revealed that PMG inhibited TNF-α-induced cytotoxicity and apoptosis in L929 cells via TNF-R1. Although PMG was a trace component in the chemical constituents of the R. officinale extract, it had considerable anti-inflammatory activities.
    CONCLUSIONS:
    It was found for the first time that PMG was a ligand for TNF receptor from herbal medicines. The proposed SPR-based screening method may prove to be an effective solution to analyzing bioactive components of Chinese herbs and other complex drug systems. Graphical abstract Scheme of the method based on SPR biosensor for screening and recovering active ingredients from complex herbal extracts and UPLC-MS for identifying them. Scheme of the method based on SPR biosensor for screening and recovering active ingredients from complex herbal extracts and UPLC-MS for identifying them.
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