Physcion 8-O-beta-D-monoglucoside

Physcion 8-O-beta-D-monoglucoside
Product Name Physcion 8-O-beta-D-monoglucoside
CAS No.: 23451-01-6
Catalog No.: CFN80399
Molecular Formula: C22H22O10
Molecular Weight: 446.4 g/mol
Purity: >=98%
Type of Compound: Anthraquinones
Physical Desc.: Powder
Targets: TNF-α
Source: The roots and rhizomes of Rheum palmatum L
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Physcion 8-O-beta-D-monoglucoside has anti-inflammatory activity, it can inhibit TNF-α-induced cytotoxicity and apoptosis in L929 cells via TNF-R1.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to:

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Molecules.2019, 24(21):E3834
  • BMC Complement Altern Med.2018, 18(1):221
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Int J Biol Macromol.2019, 126:653-661
  • Molecules2020, 25(4):892
  • Life Sci.2018, 209:498-506
  • J Med Food.2016, 19(12):1155-1165
  • BMC Complement Altern Med.2019, 19(1):11
  • Molecules.2019, 24(20):3755
  • Plant Cell Tiss Org2017, 479-486
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