Obolactone
Obolactone displays significant activity in vitro cytotoxic assays against the KB cell line.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Pharmacol Rep.2019, 71(2):289-298
Hong Kong Baptist University2023, 048330T.
Plant Methods.2017, 13:108
Food Bioscience2022, 50:102187.
Plant Cell Tiss Org2020, 1-16
Biorxiv.2020, doi: 10.1101.
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J Nat Prod. 2004 May;67(5):858-62.
Cytotoxic flavonoids and alpha-pyrones from Cryptocarya obovata.[Pubmed:
15165150 ]
METHODS AND RESULTS:
One alpha-pyrone, Obolactone (1), two chalcones, kurzichalcolactone B (2) and obochalcolactone (3), and two flavanones, oboflavanones A (4) and B (5), have been isolated from the fruits and the trunk bark of Cryptocarya obovata. The structures of the new compounds were elucidated by spectroscopic interpretations. The absolute configuration of Obolactone (1) was established by circular dichroism.
CONCLUSIONS:
Obolactone (1) and obochalcolactone (3) display significant activity in in vitro cytotoxic assays against the KB cell line. Biosynthetic pathways for oboflavanones and obochalcolactone are suggested.
