Narchinol B shows inhibitory activity against LPS-induced NO production.
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Bioorg Med Chem Lett. 2012 Jan 1;22(1):706-8.
Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages.[Pubmed:
22079762]
METHODS AND RESULTS:
The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, Narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4α,5-dimethyl-1,3-dioxo-1,2,3,4,4α,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR.
CONCLUSIONS:
Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC(50) values of 4.6-21.6 μM.
