Kanshone A
Kanshone A shows cytotoxic activity against P-388 cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Zhong Yao Cai. 2007 Jan;30(1):38-41.
Study on the active components of Nardostachys chinensis.[Pubmed:
17539300]
METHODS AND RESULTS:
To study on the active components of Nardostachys chinensis Batal, the compounds were isolated and purified by chromatographic methods, with their structures identified by spectral analysis and comparison with published data. 9 compounds were obtained and their structures were identified as acaciin, ursolie acid, octacosanol, Kanshone A, nardosinonediol, nardosinone, aristolen-9beta-ol, oleanolic acid and beta-sitosterol. Acaciin, ursolie acid and octacosanol were obtained from Nardostachys chinensis Batal. for the first time.
CONCLUSIONS:
Acaciin and ursolie are the active components of antihiotics and anti-inflammatory.
Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1183-4.
Cytotoxic sesquiterpenes from Nardostachys chinensis.[Pubmed:
8370115]
METHODS AND RESULTS:
Five cytostatic sesquiterpenes, desoxo-narchinol-A (1), nardosinone (2), debilon (3), nardosinonediol (4) and Kanshone A (5), were isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae). The steric structure of 1 was determined by nuclear Overhauser effects (NOEs) and the exciton chirality method.
CONCLUSIONS:
All five showed cytotoxic activity against P-388 cells and the structure-activity relationship of 1 was also discussed.
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