3,9-Dihydroeucomin
(+/-)-3,9-Dihydroeucomin has immunomodulatory effects, it shows inhibitory effects on PBMC proliferation activated by PHA with the IC(50) value of 19.4 microM.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Food Bioscience2023, 52:102412
Front Pharmacol.2021, 12:652860.
Neurotoxicology.2022, 91:218-227.
J Ethnopharmacol.2022, 282:114574.
Int J Mol Sci.2024, 25(17):9730.
Applied Biological Chemistry2022, 71:s13765-022-00743-5.
Wageningen University & Research2018, January 2018
J Ethnopharmacol.2024, 318(Pt B):116961.
Plant Physiol.2023, 193(3):1758-1771.
Chemistr of plant2016, 2016021195
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Molecules. 2009 May 12;14(5):1789-95.
Isolation and immunomodulatory effect of homoisoflavones and flavones from Agave sisalana Perrine ex Engelm.[Pubmed:
19471199 ]
Three known flavones and seven known homoisoflavonoids were isolated from the methanolic extract of the leaves of Agave sisalanaPerrine ex Engelm.
METHODS AND RESULTS:
Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were also evaluated for immunopharmacological activity. PBMC were used as target cells, and cell proliferation was determined by (3)H-thymidine uptake. (+/-)-3,9-Dihydroeucomin (4), dihydrobonducellin (5), and 5,7-dihydroxy-3-(4'-hydroxybenzyl)-4-chromanone (7) showed inhibitory effects on PBMC proliferation activated by PHA with IC(50) values 19.4, 73.8, and 58.8 microM, respectively.
CONCLUSIONS:
All three compounds significantly inhibited the production of IL-2 and IFN-gamma in activated PBMC in a concentration-dependent manner.
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