Methylnissolin

Methylnissolin
Product Name Methylnissolin
CAS No.: 733-40-4
Catalog No.: CFN90838
Molecular Formula: C17H16O5
Molecular Weight: 300.3 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Targets: TNF-α | IL Receptor
Source: The herbs of Astragalus sinicus L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $388/10mg
Methylnissolin is a natural product from A. membranaceus.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Ethnopharmacol.2017, 209:305-316
  • J Adv Res.2019, 17:85-94
  • J Ethnopharmacol.2019, 235:406-414
  • Life Sci.2018, 209:498-506
  • Sci Rep.2019, 9(1):4646
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Am J Chin Med.2016, 44(8):1719-1735
  • RSC Adv.2018, 32621-32636
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • FEBS Lett.2015, 589(1):182-7
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    Radix Astragali (Astragalus membranaceus) is an important traditional Chinese medicine that is widely used as a tonic to enhance the body's natural defense mechanisms.
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