Mesuaxanthone A | CAS:3561-81-7 | Manufacturer ChemFaces

Mesuaxanthone A and mesuaxanthone B are two yellow pigments.They produce varying degrees of C.N.S. depression characterised by ptosis, sedation, decreased spontaneous motor activity, loss of muscle tone, potentiation of pentobarbitone sleeping time and ether anaerthesia in mice and rats; they also exhibit anti inflammatory activity both by intraperitoneal and oral routes in rats.

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Anti-inflammatory and C.N.S. depressant activities of xanthones from Calophyllum inophyllum and Mesua ferrea[Reference: WebLink]

The xanthones of Calophyllum inophyllum and Mesua Ferrea namely, dehydrocycloguanandin (DCG), calophyllin-B (CPB), jacareubin (JR), 6-desoxy jacareubin (DJR), Mesuaxanthone A (MXA), Mesuaxanthone B (MXB) and euxanthone (EX) were screened for various pharmacological effects in experimental animals.
METHODS AND RESULTS:
All the xanthones produced varying degrees of C.N.S. depression characterised by ptosis, sedation, decreased spontaneous motor activity, loss of muscle tone, potentiation of pentobarbitone sleeping time and ether anaerthesia in mice and rats.None of the xanthones had any analgesic, antipyretic and anticonvulsant activities. The xanthones did not produce any pharmacological effect in the cardiovascular system of frogs and dogs. All the xanthones exhibited anti inflammatory activity both by intraperitoneal and oral routes in rats as tested by carrageenin induced hind paw oedema, cotton pellet granuloma and granuloma pouch techniques, in normal and adrenalectomised rats.
CONCLUSIONS:
The xanthones did not have any mast cell membrane stabilising effect, and the degranulating effect of compound 48/80, diazoxide and Won-X-100 on rat peritoneal mast cells in vitro war not prevented. JR and DJR exhibited antiulcer activity in rats. The xanthones did not alter the prothrombin time in rats.

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Constituents of Mesua ferrea L.—I : Mesuaxanthone A and mesuaxanthone B[Reference: WebLink]

METHODS AND RESULTS:
Two new yellow pigments, Mesuaxanthone A and mesuaxanthone B, and the known euxanthone have been isolated from the heartwood extracts of Mesua ferrea L.
CONCLUSIONS:
Evidence is presented to show that Mesuaxanthone A is 1,5-dihydroxy-3-methoxy-xanthone and mesuaxanthone B is 1,5,6-trihydroxyxanthone. Mesuaxanthone A has been synthesized.

Product Name	Mesuaxanthone A
CAS No.:	3561-81-7
Catalog No.:	CFN98472
Molecular Formula:	C₁₄H₁₀O₅
Molecular Weight:	258.2 g/mol
Purity:	>=98%
Type of Compound:	Xanthones
Physical Desc.:	Yellow powder
Source:	The herbs of Calophyllum inophyllum L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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