Macrocarpal C
Macrocarpal C, isolated from the fresh leaves of Eucalyptus globulus Labill. (Lan An) and identified as its major antifungal component by bioassay-guided purification, the antifungal action of macrocarpal C was associated with increases of membrane permeability, intracellular ROS and DNA fragmentation.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Am J Chin Med. 2010;38(5):1005-14.
Two antifungal components isolated from Fructus Psoraleae and Folium Eucalypti Globuli by bioassay-guided purification.[Pubmed:
20821830]
Fructus Psoraleae and Folium Eucalypti Globuli have long been used as Chinese medicines to treat various ailments such as asthma, eczema and dermatomycosis. In previous studies, their antifungal activities were demonstrated. The aim of the present study was to isolate active antidermatophytic compounds from their ethanolic extracts by means of bioassay-guided purification.
METHODS AND RESULTS:
Guided by the inhibitory activities on Trichophyton mentagrophytes, Trichophyton rubrum and Paecilomyces variotii, bakuchiol was isolated from the n-hexane fraction of Fructus Psoraleae whilst Macrocarpal C was isolated from the n-hexane fraction of Folium Eucalypti Globuli. Both pure compounds could effectively inhibit the growth of dermatophytes in vitro.
CONCLUSIONS:
This is the first paper to report the isolation and identification of active antidermatophytic compounds from Fructus Psoraleae and Folium Eucalypti Globuli by the bioassay-guided purification.
Chin Med. 2015 Nov 21;10:34.
Antifungal mode of action of macrocarpal C extracted from Eucalyptus globulus Labill (Lan An) towards the dermatophyte Trichophyton mentagrophytes.[Pubmed:
26594235 ]
The fresh leaves of Eucalyptus globulus Labill. (Lan An) have been used in Chinese medicine for many years to treat dermatomycosis. Macrocarpal C was isolated from this herb and identified as its major antifungal component by bioassay-guided purification.
This study aims to investigate the antifungal activity of Macrocarpal C against Trichophyton mentagrophytes, which can cause tinea pedis.
METHODS AND RESULTS:
The suppression in the growth of T. mentagrophytes following its treatment with Macrocarpal C was associated with an increase in the permeability of the fungal membrane (P = 0.0043 when compared to control); an increase in the production of intracellular ROS (P = 0.0063); and the induction of apoptosis as a consequence of DNA fragmentation (P = 0.0007). CONCLUSION:
CONCLUSIONS:
This study demonstrated that the antifungal action of Macrocarpal C was associated with increases of membrane permeability, intracellular ROS and DNA fragmentation.
J Nat Prod. 2013 Dec 27;76(12):2346-9.
Semisynthesis of macrocarpal C and analogues by selective dehydration of macrocarpal A or B.[Pubmed:
24261967]
METHODS AND RESULTS:
Macrocarpal A and Macrocarpal C are structurally related compounds that have been extracted from different Eucalyptus species. Although Macrocarpal C is of biological interest, its isolation in pure form is difficult to achieve.
CONCLUSIONS:
We report herein an efficient method for the semisynthesis of Macrocarpal C by selective exo-dehydration of another member of the macrocarpal family, macrocarpal A.
We also report the semisynthesis of three new macrocarpal structures derived from either macrocarpal A or B.
