Luteolin-4'-O-glucoside
Luteolin 4'-O-glucoside as a IL-5 inhibitor, it has anti-complementary,and anti-oxdiant activities.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Pharmaceutical Chemistry Journal2019, 52(12):986-991
Pharmaceuticals (Basel).2020, 13(9):262.
Metabolites.2020, 11(1):E11.
Journal of Phytopathology2021, 169,Issue11-12.
Planta Med.2016, 82(13):1208-16
J Drug Target.2016, 24:1-28
Nutrients2022, 14(3),695.
Int J Pharmacol2020, 16:1-9
Pharmaceutics.2020, 12(9):882.
J Nat Prod.2022, doi: 10.1021
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Pharmazie. 1996 Oct;51(10):765-8.
In vitro anti-complementary activity of flavonoids from olive (Olea europaea L.) leaves.[Pubmed:
8941947]
METHODS AND RESULTS:
From extracts of olive (Olea europaea L., Oleaceae) leaves showing anti-complementary activity, the flavonoids apigenin, apigenin-4'-O-rhamnosylglucoside, apigenin-7-O-glucoside, luteolin, Luteolin-4'-O-glucoside, luteolin-7-O-glucoside, chrysoeriol, chrysoeriol-7-O-glucoside and quercetin-3-O-rhamnoside were isolated.
CONCLUSIONS:
Major isolated constituents strongly inhibited the classical pathway of the complement system.
Journal of the Korean Society of Food Science & Nutrition, 2004, 33(9).
Isolation of Antioxidant and Antibrowning Substance from Chionanthus retusa Leaves[Reference:
WebLink]
METHODS AND RESULTS:
This study was performed to examine in vitro antioxidative activities such as DPPH radical scavenging activity, reducing power and tyrosinase inhibitory effect of various solvent fractions from Chionanthus retusa leaves.
Ethyl acetate fraction showed potent antioxidative activity and tyrosinase inhibitory effect. The active compound was isolated from the butanol fraction by silica gel column chromatography and MPLC. The isolated compound was Luteolin-4'-O-glucoside determined by , -NMR and 2D NMR. Compared with several antioxidant compounds, Luteolin-4'-O-glucoside exhibited effective DPPH radical scavenging activity and reducing power in a concentration dependent manner. Bioassay with pure Luteolin-4'-O-glucoside showed a dose-independent inhibitory effect on L-DOPA oxidation by mushroom tyrosinase and its values were established as 23.2 .
CONCLUSIONS:
Therefore, we may suggest that Luteolin-4'-O-glucoside can be used as a food additive possessing the potent antioxidative activity and skin-whitening cosmetic material.
J Ethnopharmacol. 2000 Jun;70(3):213-7.
Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae).[Pubmed:
10837985]
METHODS AND RESULTS:
Polar fractions and flavones isolated from methanolic extracts of the leaves of Ligustrum vulgare and Phillyrea latifolia (Oleaceae), whose popular use as an anti-inflammatory is well-known in Mediterranean historical medicine and ethnobotany, showed significant in vitro complement inhibiting effect on the classical pathway of the complement system.
CONCLUSIONS:
Among the isolated flavonoidic structures, apigenin-7-O-glucoside, apigenin-7-O-rutinoside, Luteolin-4'-O-glucoside, luteolin-7-O-glucoside and ligustroflavone presented remarkable activity.
Planta Med. 1999 Jun;65(5):457-9.
Inhibitory effect of luteolin 4'-O-glucoside from Kummerowia striata and other flavonoids on interleukin-5 bioactivity.[Pubmed:
10418337 ]
Interleukin (IL)-5 is a chemotactic factor of eosinophils, and promotes the growth and survival of eosinophils, which plays an important role in the eosinophilia-associated allergic inflammation.
METHODS AND RESULTS:
In this study, luteolin-4'-O-glucopyranoside(Luteolin-4'-O-glucoside ) was identified as the IL-5 inhibitor from Kummerowia striata Thunb. (Leguminosae) by activity-guided fractionation followed by structural analysis compared with reported spectral data. The flavone compound exhibited dose-dependent inhibitory effect on IL-5 bioactivity with 95% inhibition at 30 microM, 79% at 15 microM, 60% at 7.5 microM, 54% at 3.8 microM and 29% at 1.9 microM, where 50% of inhibition (IC50) value was shown at the concentration of 3.7 microM. Furthermore, the inhibitory effect on IL-5 bioactivity by other flavonoid compounds available was estimated.
CONCLUSIONS:
In view of the IC50 values, the inhibitory potency on IL-5 bioactivity was in order of luteolin-4'-O-glucopyranoside > cosmosiin (14.2 microM) approximately equal to apigenin (16.4 microM) approximately equal to luteolin (18.7 microM) > quercimeritrin (27.3 microM) approximately equal to kaempferol (30.0 microM).
