Ganoderenic acid D

Ganoderenic acid D
Product Name Ganoderenic acid D
CAS No.: 100665-43-8
Catalog No.: CFN90300
Molecular Formula: C30H40O7
Molecular Weight: 512.64 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The fruit body of Ganoderma lucidum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $476/10mg
Ganoderenic acid D is most cytotoxic with IC50 values of 0.14 ± 0.01, 0.18 ± 0.02 and 0.26 ± 0.03 mg/mL in Hep G2, Hela and Caco-2 cells, respectively.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Chemistry of Natural CompoundsJan. 2018;
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  • Biochem Pharmacol. 2017 Apr 15;
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  • Int J Oncol. 2016 Oct;49(4)
  • Food Res Int. 2017 Jun;
  • Lab On a Chip21 Feb 2018;
  • Food Research InternationalJan. 2016
  • Pharm Biol. 2017 Dec;
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    Natural Product Research, Volume 28, Number 24, 17 December 2014, pp. 2264-2272(9)
    Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth[Reference: WebLink]
    The response surface methodology was used to optimise the extraction conditions of Ganoderma lucidum based on a Box–Behnken design.
    METHODS AND RESULTS:
    A quadratic model sufficiently simulated the response of ganoderic acid H with a determination coefficient (R 2) of 0.98. The optimal condition for extracting triterpenoids was determined to be 100.00% ethanol at 60.22°C for 6.00 h, under which the yield of the reference triterpenoid ganoderic acid H increased from 0.88 to 2.09 mg/g powder. Following extraction, triterpenoid-enriched fraction was further isolated into 23 fractions, and 7 fractions were identified as ganoderic acids A, B, D, G, H and I and Ganoderenic acid D. Of the seven triterpenoids, Ganoderenic acid D was most cytotoxic with IC50 values of 0.14 ± 0.01, 0.18 ± 0.02 and 0.26 ± 0.03 mg/mL in Hep G2, Hela and Caco-2 cells, respectively. While ganoderic acids A, G and H were relatively non-cytotoxic.
    CONCLUSIONS:
    The variation of inhibitory effects for these triterpenoids was likely related to their chemical structures.
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