Lobeline sulfate
Lobeline sulfate has toxicity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Veterinary and Human Toxicology, 01 Feb 1985, 27(1):1-2.
Effects of SKF 525-A, phenobarbital and 3-methylcholanthrene on the toxicity of lobeline sulfate.[Reference:
WebLink]
METHODS AND RESULTS:
Pretreatment of mice with the microsomal enzyme inducers and inhibitors modified the toxicity of Lobeline sulfate. The intraperitoneal LD50 of Lobeline sulfate following SKF 525-A (75 mg/kg), phenobarbital (PB), and 3-methylcholanthrene (3-MC) were 18.3, 85.5 and 82.1 mg/kg, respectively, as compared to that of saline treated controls, 55.3 mg/kg. Pretreatment of mice with disulfiram (DSF), diethylmaleate (DEM), or ethoxyquin hydrochloride (EQ-HC1) exhibited a very slight effect on the toxicity of Lobeline sulfate.
CONCLUSIONS:
These results suggest that the hepatic microsomal monooxygenase system, but not glutathione (GSH), is involved in the detoxication of Lobeline sulfate.
