Liquiritin apioside

Liquiritin apioside
Product Name Liquiritin apioside
CAS No.: 199796-12-8
Catalog No.: CFN90707
Molecular Formula: C26H30O13
Molecular Weight: 550.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Targets: TNF-α | TGF-β/Smad
Source: The roots of Glycyrrhiza uralensis Fisch
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $288/20mg
Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress, might be as protective agent against epithelial injury in COPD.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • Biomed Chromatogr.2019, 8:e4774
  • Sci Rep.2017, 7(1):3249
  • Nat Commun.2019, 10(1):2745
  • Biofactors.2018, 44(2):168-179
  • Phytochem Anal.2016, 27(5):296-303
  • Int J Mol Sci.2019, 20(9):E2244
  • Scientific World Journal.2014, 2014:654193
  • Molecules.2018, 23(3):E615
  • Spectrochim Acta A2019, 210:372-380
  • Isosakuranin

    Catalog No: CFN92809
    CAS No: 491-69-0
    Price: $318/10mg
    Poncirin

    Catalog No: CFN90448
    CAS No: 14941-08-3
    Price: $218/20mg
    Didymin

    Catalog No: CFN92363
    CAS No: 14259-47-3
    Price: $128/20mg
    Hemiphloin

    Catalog No: CFN91855
    CAS No: 71963-94-5
    Price: $318/5mg
    Isohemiphloin

    Catalog No: CFN98602
    CAS No: 3682-02-8
    Price: $318/5mg
    Farrerol 7-O-glucoside

    Catalog No: CFN96281
    CAS No: 885044-12-2
    Price: Inquiry(manager@chemfaces.com)
    Flavaprin

    Catalog No: CFN98900
    CAS No: 53846-49-4
    Price: Inquiry(manager@chemfaces.com)
    Liquiritin

    Catalog No: CFN99154
    CAS No: 551-15-5
    Price: $60/20mg
    Liquiritin apioside

    Catalog No: CFN90707
    CAS No: 199796-12-8
    Price: $288/20mg
    Glucoliquiritin

    Catalog No: CFN95011
    CAS No: 93446-18-5
    Price: $318/10mg
    Fundam Clin Pharmacol. 2012 Aug;26(4):473-83.
    Protective effects of liquiritin apioside on cigarette smoke-induced lung epithelial cell injury. [Pubmed: 21631586]
    Cigarette smoking is associated with an increased incidence of chronic obstructive pulmonary disease (COPD).
    METHODS AND RESULTS:
    In this study, we hypothesized that Liquiritin apioside (LA), a main flavonoid component from Glycyrrhiza uralensis, had antioxidant properties by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress. A549 cells were treated with cigarette smoke extract (CSE) and/or LA. ICR mice were exposed to cigarette smoke (CS) for four days with increasing exposure time for up to 6 h per day to elicit epithelial cells injury. One hour before smoke exposure, mice were treated with LA by gavage; 18 h after the last CS exposure all examinations were performed. Treatment with LA concentration-dependently prevented CSE-induced cytotoxicity, increase of TGF-β and TNF-α mRNA expression, depletion of GSH and apoptosis in A549 cells. LA at doses 3, 10 and 30 mg/kg dose-dependently inhibited pulmonary neutrophil and macrophage inflammation. Lung sections of the CS-exposed LA treated mice showed an apparently reduced pulmonary inflammation and a significant inhibitory effect on mucus containing goblet cells in the large airways. Furthermore, the CS-induced pulmonary release of TGF-β, TNF-α and myeloperoxidase activity was reduced, and superoxide dismutase activity was enhanced.
    CONCLUSIONS:
    These results indicate that protective roles of LA on CS-induced the lung epithelial cell injury are mediated by inhibiting TGF-β and TNF-α expression and increasing anti-oxidative levels of GSH, suggesting that LA might be effective as protective agent against epithelial injury in COPD.
    Hinokiflavone

    Catalog No: CFN92007
    CAS No: 19202-36-9
    Price: $318/10mg
    Pallidol

    Catalog No: CFN92341
    CAS No: 105037-88-5
    Price: $318/10mg
    Ginsenoside Rk3

    Catalog No: CFN92593
    CAS No: 364779-15-7
    Price: $180/10mg
    Ebracteolata cpd B

    Catalog No: CFN92882
    CAS No: 83459-37-4
    Price: $268/10mg
    Clemastanin B

    Catalog No: CFN95064
    CAS No: 112747-98-5
    Price: $298/10mg
    Mirificin-4'-O-glucoside

    Catalog No: CFN95091
    CAS No: 168035-01-6
    Price: $288/5mg
    1,3,6-Trihydroxy-2-methylanthraquinone 3-O-alpha-L-rhamnosyl-(1->2)-beta-D-glucoside

    Catalog No: CFN95096
    CAS No: 87686-88-2
    Price: $318/5mg
    Cassiaside C

    Catalog No: CFN95120
    CAS No: 119170-52-4
    Price: $318/10mg
    Yuanhuanin

    Catalog No: CFN95127
    CAS No: 83133-14-6
    Price: $318/5mg
    Puerol B

    Catalog No: CFN95155
    CAS No: 112343-17-6
    Price: $398/5mg