Linderaspirone A
Linderaspirone A shows significant activity against glucosamine-inducedinsulin resistance.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Org Lett. 2011 May 6;13(9):2192-5.
Biomimetic total syntheses of linderaspirone A and bi-linderone and revisions of their biosynthetic pathways.[Pubmed:
21446662]
METHODS AND RESULTS:
Simple exposure to sunlight is sufficient for triggering photochemical [2 + 2] cycloaddition-Cope or radical rearrangement cascades in the naturally occurring methyl linderone, leading to efficient biomimetic total syntheses of Linderaspirone A and bi-linderone, two recently discovered bioactive spirocyclopentenedione natural products.
Org Lett. 2010 Jul 16;12(14):3196-9.
A pair of windmill-shaped enantiomers from Lindera aggregata with activity toward improvement of insulin sensitivity.[Pubmed:
20545338]
METHODS AND RESULTS:
(+)-Linderaspirone A and (-)-Linderaspirone A, a pair of natural windmill-shaped enantiomers, were isolated from the traditional Chinese medicine plant Lindera aggregate by HPLC using a chiral column, achieving over 98% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra, crystal X-ray diffraction, and calculation of the optical rotations (OR).
CONCLUSIONS:
They have an unprecedented carbon skeleton and showed significant activity against glucosamine-induced insulin resistance.
