Fraxidin
Reference standards.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Phytomedicine2022, 104:154337.
Pharmacia2022, 69(3): 883-890.
Biosci Biotechnol Biochem.2021, 85(10):2153-2160.
Front Pharmacol.2021, 12:690113.
J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
Pharmacol Rep.2019, 71(2):289-298
Int J Mol Sci.2020, 21(24):9369.
Applied Biological Chemistry2021, 64(4)
Analytical Letters.2020, doi 10.1008
Food Sci Biotechnol.2016, 25(5):1437-1442
Related and Featured Products
Planta Med. 1999 Oct;65(7):656-8.
In vitro inducible nitric oxide synthesis inhibitory active constituents from Fraxinus rhynchophylla.[Pubmed:
10575381 ]
METHODS AND RESULTS:
Bioassay-guided fractionation of an H2O extract of the barks of Fraxinus rhynchophylla has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, ferulaldehyde (1) and scopoletin (3) together with a coumarin, Fraxidin (2).
CONCLUSIONS:
Compounds 1 and 3 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner by murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was reflected in the decreased amount of iNOS protein, as determined by Western blotting.
