Linderalactone

Nat Prod Res. 2005 Apr;19(3):283-6.

Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma.[Pubmed: 15702642]

METHODS AND RESULTS:
Six furanogermacrane sesquiterpenes, pseudoneolinderane (1), Linderalactone (2), zeylanidine (3), zeylanicine (4), deacetylzeylanidine (5), and neolitrane (6), isolated from the stems of Neolitsea parvigemma, were tested for anti-inflammatory activities.
CONCLUSIONS:
Among them, 1 and 2 showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB. The IC50 of 1 and 2 were found to be 3.21 and 8.48 microg/mL, respectively.

J Nat Prod. 2009 Aug;72(8):1497-501.

Sesquiterpene lactones from the root tubers of Lindera aggregata.[Pubmed: 19639966]

Phytochemical investigation of the root tubers of Lindera aggregata resulted in the isolation of five new sesquiterpene lactones, linderagalactones A-E (1-5), along with eight known sesquiterpenoids, 3-eudesmene-1beta,11-diol, hydroxylindestenolide, strychnistenolide, hydroxyisogermafurenolide, atractylenolide III, linderane, neoLinderalactone, and Linderalactone.
METHODS AND RESULTS:
The structures and relative configurations of 1-5 were determined by spectroscopic methods, especially HRESIMS and 2D NMR techniques. The absolute configurations of 1-4 were defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Linderagalactone A (1) is a halogenated sesquiterpene lactone possessing a unique rearranged carbon skeleton. Linderagalactone E (5), linderane, hydroxylindestenolide, and Linderalactone showed hepatoprotective activity against H2O2-induced oxidative damages on HepG2 cells with EC(50) values of 67.5, 167.0, 42.4, and 98.0 microM, respectively.

Zhongguo Zhong Yao Za Zhi. 2001 Nov;26(11):765-7.

Studies on constituents of the leaves of Lindera aggregata (Sims) Kosterm.[Pubmed: 12776349]

To study the antibacterial and anti-inflammatory constituents of the leaves of Lindera aggrega.
METHODS AND RESULTS:
Compounds were isolated by colum chromatography, and the structures were identified by spectroscopic methods. Six compounds were isolated and identified as mixture of 6-Acetyllindenanolide B-1 and B-2(I), dehydrolindestrenolide (II), hydroxylinderstrenolide (III), Linderalactone (IV), kameofero (V), beta-sitosterol (VI).
CONCLUSIONS:
These compounds were obtained from the leaves of Lindera aggregata for the first time.