Isovanillic acid

Pharmacogn Mag. 2016 Jan;12(Suppl 1):S47-51.

New Isorhamnetin Derivatives from Salsola imbricata Forssk. Leaves with Distinct Anti-inflammatory Activity.[Pubmed: 27041858]

METHODS AND RESULTS:
All chemical structures were identified on the basis of electrospray ionization -mass spectrometry, one- and two-dimension nuclear magnetic resonance. Nine phenolic compounds, among them two new natural products ; isorhamnetin -3-O-β-D-glucuronyl (1′″→4″) glucuronide (1) and its dimethyl ester ; isorhamnetin -3-O-βD-di glucuronate dimethyl ester (2), two isorhamnetin glycosides : Isorhamnetin -3-O-β-D-galactopyranoside (3), isorhamnetin -3-O-β-D-glucopyranoside (4), and isorhamnetin (5). In addition, an alkaloidal phenolic ; trans N-feruloyl tyramine (6), three phenolic acids: Isovanillic acid (7), ferulic acid (8), and p-hydroxy benzoic acid (9) were isolated from salsola imbricata leaves. All compounds were isolated and identified for the first time from this plant except compound (6). The extract and the tested compounds showed distin ct anti -inflammatory activities with no toxicity on RAW 264.7 macrophage cells.
CONCLUSIONS:
Therfore, extract and the tested compounds showed distinct anti-inflammatory activities with no toxicity on RAW 264 so it may become targets for anti -inflammation drugs developmen.

Zhong Yao Cai. 2012 Oct;35(10):1610-4.

Study on chemical composition of ethylacetate fraction from Polygonum amplexicaule var. sinense.[Pubmed: 23627126]

To study chemical composition of ethylacetate fraction from Polygonoum amplexicaule D. Don var. sinense Forb.
METHODS AND RESULTS:
TLC, Normal-phase silica gel column, reveres-phase silica gel column, Sephadex-LH, semi-preparative HPLC column were used to isolate chemical compositions of ethylacetate fraction from Polygonoum var. sinense. RESULTS: Eight compounds were identified as: 1. P-Hydroxybenzoic acid, 2. P-Hydroxybenzoic ethanol, 3. Diisobutyl phthalate, 4. Vanillin, 5. Isovanillic acid, 6.3,4,5-trihydroxy-benzoic acid-butyl ester, 7. 4-hydroxy-3-methoxycinnamic acid, 8. 7-hydroxy-6-methoxycoumarin.
CONCLUSIONS:
Except of Diisobutyl phthalate, the others are isolated for the first from this plant, moreover, Vanillin, Isovanillic acid and P-hydro -xyphenethyl alcohol are gained from genus for the first time.

Zhong Yao Cai. 2013 Nov;36(11):1774-8.

Chemical constituents from the roots of Ilex pubescens.[Pubmed: 24956816]

METHODS AND RESULTS:
The 95% ethanol extract of the plant was separated by silica gel, Sephadex LH-20 and preparative HPLC chromatography. The structures were elucidated based on the physiochemical properties and spectroscopic analysis. Fifteen compounds were isolated and identified as oleuropein(1), oleoside dimethyl ester(2),8 (Z)-nuezhenide(3),3,4-dicaffeoylquinic acid methyl ester(4),3,4,5-tricaffeoylquinic acid methyl ester (5), Isovanillic acid(6), syringic acid(7), 3beta-acetyloleanolic acid (8), 3beta-acetylursolic acid(9), uvaol(10), asiatic acid(11), 2alpha-hydroxyursolic acid(12), oleanolic acid (13), ursolic acid (14), stigmasterol-3-O-beta-D-glucopyranoside (15).
CONCLUSIONS:
Compounds 2,3,8,9 are obtained from this genus for the first time,compounds 5-7,10-12 are isolated from this plant for the first time.