1-Phenylbutane-1,3-dione
The starting 1-phenylbutane-1,3-dione is used as key intermediate for the synthesis of several new thiophene and pyrazole derivatives.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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The Japan Society for Analytical Chemistry2018, 67(4):201-206
Int J Biol Macromol.2020, 161:1230-1239.
J of Pharmaceutical Analysis2020, doi: 10.1016
Nat Commun.2021, 12(1):681.
Korean J of Food Science&Technology 2017, 49(2):146-150
ACS Omega.2023, 9(1):1278-1286.
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Korean Journal of Pharmacognosy.2019, 50(1):65-71
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Pharmacology & Pharmacy, 2012 , 3 (2) :148-57.
Synthesis of Some New Arylazothiophene and Arylazopyrazole Derivatives as Antitumor Agents[Reference:
WebLink]
The starting 1-Phenylbutane-1,3-dione (1) was used as key intermediate for the synthesis of several new thiophene and pyrazole derivatives.
METHODS AND RESULTS:
The newly synthesized compounds were evaluated for cytotoxicity against an Ehrlich ascites cells and cytotoxicity for compound 10d using EAC assay and 5-fluorouracil is used as reference drug. Compounds 7c, e and 10c, d showed significant activity in certain cancer cell and have been targeted for further studies, compound 10d is more effective and showed the highest activity. Structures of the newly prepared compounds were confirmed by both spectral, analytical data and molecular calculations.
