Isomucronulatol

Isomucronulatol
Product Name Isomucronulatol
CAS No.: 52250-35-8
Catalog No.: CFN90839
Molecular Formula: C17H18O5
Molecular Weight: 302.3 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Targets: TNF-α | IL Receptor | AChR
Source: The roots of Astragalus membranaceus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $218/10mg
Isoliquiritigenin and liquiritigenin exhibit significant inhibitory effects on LPS-induced IL-6 and IL-12 p40 production, with IC 50 values ranging from 2.7 to 6.102uM, isoliquiritigenin also shows a moderate inhibitory effect on LPS-stimulated production of TNF-α with an IC 50 value of 20.102 uM, they have potential anti-inflammatory effects. Isomucronulatol exhibits noticeable ABTS+ scavenging activity, it exhibits moderate inhibition against butyrylcholinesterase.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • Bio-protocol2018, 9(14):e3301
  • Scientific World Journal.2014, 2014:654193
  • Oncol Rep.2019, 41(4):2453-2463
  • BMC Microbiol.2019, 19(1):78
  • Sci Rep.2019, 9(1):4646
  • Int J Mol Sci.2018, 19(9):E2601
  • J Cell Mol Med.2018, 22(9):4236-4242
  • Biomed Pharmacother.2019, 111:262-269
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Erythbidin A

    Catalog No: CFN96547
    CAS No: 210050-83-2
    Price: Inquiry(manager@chemfaces.com)
    Glabrene

    Catalog No: CFN96402
    CAS No: 60008-03-9
    Price: Inquiry(manager@chemfaces.com)
    Dehydroglyasperin C

    Catalog No: CFN96483
    CAS No: 199331-35-6
    Price: Inquiry(manager@chemfaces.com)
    Glyasperin C

    Catalog No: CFN95065
    CAS No: 142474-53-1
    Price: $333/5mg
    Licoricidin

    Catalog No: CFN96389
    CAS No: 30508-27-1
    Price: $388/5mg
    Licorisoflavan A

    Catalog No: CFN96372
    CAS No: 129314-37-0
    Price: Inquiry(manager@chemfaces.com)
    Demethylvestitol

    Catalog No: CFN96183
    CAS No: 65332-45-8
    Price: Inquiry(manager@chemfaces.com)
    Vestitol

    Catalog No: CFN98483
    CAS No: 35878-41-2
    Price: $333/5mg
    Isosativan

    Catalog No: CFN97016
    CAS No: 60102-29-6
    Price: Inquiry(manager@chemfaces.com)
    (-)-Sativan

    Catalog No: CFN89475
    CAS No: 41743-86-6
    Price: Inquiry(manager@chemfaces.com)
    Arch. Pharm. Res. 2014, 37(2):186-92.
    Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells.[Pubmed: 23771500 ]
    Radix Astragali (Astragalus membranaceus) is an important traditional Chinese medicine that is widely used as a tonic to enhance the body's natural defense mechanisms.
    METHODS AND RESULTS:
    In this phytochemical study, 12 flavonoids, isoliquiritigenin (1), liquiritigenin (2), calycosin (3), calycosin 7-O-β-D-glucoside (4), formononetin (5), formononetin 7-O-β-D-glucoside (6), daidzein (7), daidzein 7-O-β-D-glucoside (8), methylnissolin (9), methylnissolin 3-O-β-D-glucoside (10), Isomucronulatol (11), and Isomucronulatol 7-O-β-D-glucoside (12), were isolated from the roots of A. membranaceus. Their structures were elucidated by comparing spectroscopic data with reported values. The effects of the isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated.
    CONCLUSIONS:
    Compounds 1 and 2 exhibited significant inhibitory effects on LPS-induced IL-6 and IL-12 p40 production, with IC50 values ranging from 2.7 to 6.1 μM. Compound 1 also showed a moderate inhibitory effect on LPS-stimulated production of TNF-α with an IC50 value of 20.1 μM. Further studies of the potential anti-inflammatory effects and benefits of flavonoids from A. membranaceus are warranted.
    Food Chem. 2011, 126(1):31-8.
    Antioxidant and anticholinesterase active constituents from Micromeria cilicica by radical-scavenging activity-guided fractionation[Reference: WebLink]

    METHODS AND RESULTS:
    From the acetone extract of Micromeria cilicica, two new (1 and 2) and five known (3–7) compounds were obtained through radical-scavenging activity guided isolation. Structures of the compounds were identified as piperitone 7-O-β-d-glucoside (1), isothymonin 4′-methyl ether (2), sudachitin (3), Isomucronulatol (4), rutin (5), ursolic acid (6) and saccharose (7), based on UV, 1D-and 2D-NMR and mass spectroscopic techniques. The antioxidant potentials of the extract and the isolated compounds were established by using three radical-scavenging assays, namely, DPPH scavenging, O2- scavenging and ABTS+ scavenging, besides β-carotene bleaching assay. Particularly, the acetone extract showed a strong inhibition of lipid peroxidation by β-carotene bleaching assay, with a result close to that of (+)-catechin.
    CONCLUSIONS:
    Among the pure compounds, rutin (5) showed the strongest lipid peroxidation inhibition and antiradical activity while both sudachitin (3) and Isomucronulatol (4) exhibited noticeable ABTS+ scavenging activity. The anticholinesterase activity of the compounds (1–7) was also determined. Against acetylcholinesterase, they exhibited weak inhibition while compounds 3, 4 and 6 exhibited moderate inhibition against butyrylcholinesterase.
    Ganoderic acid B

    Catalog No: CFN92052
    CAS No: 81907-61-1
    Price: $328/10mg
    Tubuloside A

    Catalog No: CFN90669
    CAS No: 112516-05-9
    Price: $218/20mg
    Ginsenoside F4

    Catalog No: CFN90757
    CAS No: 181225-33-2
    Price: $318/10mg
    Glucoliquiritin

    Catalog No: CFN95011
    CAS No: 93446-18-5
    Price: $318/10mg
    7-Neohesperidosides

    Catalog No: CFN95018
    CAS No: 28383-41-7
    Price: $288/5mg
    Licoarylcoumarin

    Catalog No: CFN95072
    CAS No: 125709-31-1
    Price: $413/5mg
    (Z)-Aldosecologanin (Centauroside)

    Catalog No: CFN95079
    CAS No: 82474-97-3
    Price: $388/5mg
    Tuberosin

    Catalog No: CFN95107
    CAS No: 41347-45-9
    Price: $218/5mg
    Asiaticoside B

    Catalog No: CFN95124
    CAS No: 125265-68-1
    Price: $198/20mg
    Schisphenin E

    Catalog No: CFN95223
    CAS No: 1311376-52-9
    Price: $388/5mg