Isodunnianol
Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the primary cultured rat cortical neurons. Isodunnianol, dunnianol, and Macranthol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5 -3.0 fold and decrease cellular oxidative stress by 40-65%, they show substantial activity against iNOS.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Microchemical Journal2024, 200:110475
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Biochem Biophys Res Commun.2017, 482(4):1095-1101
Russian J Bioorganic Chemistry 2021, 47:1411-1417.
Spectrochim Acta A2019, 210:372-380
Br J Pharmacol.2024, 181(24):5009-5027.
Phytomedicine.2018, 47:48-57
Eur J Pharmacol.2020, 889:173589.
J. Pharm. Biomed. Anal.2024, 245:116193.
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Tetrahedron, 2007,63(20): 4243–4249.
Structure and neurotrophic activity of novel sesqui-neolignans from the pericarps of Illicium fargesii[Reference:
WebLink]
METHODS AND RESULTS:
The structures of three new sesqui-neolignans, fargenin (1) and fargenones A and B (2 and 3), together with two previously known sesqui-neolignans, macranthol (4) and Isodunnianol (5), isolated from the methanol extract of the pericarps of Illicium fargesii were elucidated on the basis of spectroscopic data. Compounds 1–3 are the second three examples of the sesqui-neolignans that contain a variety of non-aromatic rings, and their plausible biosynthetic routes from chavicol are proposed.
CONCLUSIONS:
Among the isolated sesqui-neolignans, Isodunnianol has been found to exhibit neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 μM in the primary cultured rat cortical neurons.
Planta Med.,2014, 80(10):807-807.
Compounds from the bark of Illicium tsaii and their anti-inflammatory activity[Reference:
WebLink]
Illicium tsaii is a Chinese native species growing in northwest China. The bark of I. tsaii, has been applied for the treatment of rheumatoid arthritis. Phytochemical investigation on this species resulted in the isolation and characterization of 28 compounds from the stem bark of I. tsaii.
METHODS AND RESULTS:
Structure determination was accomplished by means of spectroscopic data interpretation. The biological activity of the isolated compounds was evaluated toward multiple targets related to inflammation such as NAG-1, NF-κB, iNOS and ROS. Sesquilignans showed significant activity, among which dunnianol, macranthol and Isodunnianol increased NAG-1 activity 1.5 – 3.0 fold and decreased cellular oxidative stress by 40 – 65%.
CONCLUSIONS:
These three compounds showed substantial activity against iNOS, while only macranthol showed activity against NF-κB. This is the first study on the constituents of I. tsaii and evaluation of their biological activity.
Natural Products and Bioprospecting,2012,2(3):133-137.
Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity[Reference:
WebLink]
Three new sesquilignans, 1–3, a new sesquiterpenoid, 4, and three known compounds were isolated from the stem barks of Illicium simonsii.
METHODS AND RESULTS:
The structures of new compounds (1–4) were elucidated by spectroscopic methods. A biosynthetic pathway was proposed for simonsienols A-C (1–3). Anti-AChE activity and anti-BuChE activity were evaluated for all compounds except for α-cadinol ethyl ether (4).
CONCLUSIONS:
As a result, Isodunnianol (7) exhibited anti-AChE activity with an IC50 value of 13.0 µM.
