Hinokiflavone

Hinokiflavone
Product Name Hinokiflavone
CAS No.: 19202-36-9
Catalog No.: CFN92007
Molecular Formula: C30H18O10
Molecular Weight: 538.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: MMP(e.g.TIMP)
Source: The leaves of Platycladus orientalis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $318/10mg
Hinokiflavone has significant cytotoxicity, it has inhibition of MMP-9.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Ethnopharmacol.2017, 198:205-213
  • Comput Biol Chem.2019, 83:107096
  • Molecules.2019, 24(21):E3834
  • J of the Society of Cosmetic Scientists of Korea2018, 44(4):407-417
  • Nutr Res Pract2019, 13:e45
  • Biochemistry.2018, 57(40):5886-5896
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Universite de Bordeaux2017, 2017BORD0867
  • Molecules.2019, 24(24),4583
  • Pharmacogn Mag.2015, 11:S585-91
  • Hinokiflavone

    Catalog No: CFN92007
    CAS No: 19202-36-9
    Price: $318/10mg
    Neocryptomerin

    Catalog No: CFN91949
    CAS No: 20931-36-6
    Price: Inquiry(manager@chemfaces.com)
    2,3-Dihydrohinokiflavone

    Catalog No: CFN96390
    CAS No: 34292-87-0
    Price: Inquiry(manager@chemfaces.com)
    Taiwanhomoflavone B

    Catalog No: CFN98808
    CAS No: 509077-91-2
    Price: Inquiry(manager@chemfaces.com)
    Imbricataflavone A

    Catalog No: CFN91946
    CAS No: 133336-96-6
    Price: Inquiry(manager@chemfaces.com)
    2,3,2'',3''-Tetrahydroochnaflavone

    Catalog No: CFN97157
    CAS No: 678138-59-5
    Price: Inquiry(manager@chemfaces.com)
    Planta Med. 1989 Apr;55(2):166-8.
    Hinokiflavone, a cytotoxic principle from Rhus succedanea and the cytotoxicity of the related biflavonoids.[Pubmed: 2526343]
    Hinokiflavone (1) was isolated as the cytotoxic principle from the drupes of Rhus succedanea L.
    METHODS AND RESULTS:
    A comparison of the cytotoxicity of 1 and other related biflavonoids, including amentoflavone (2), robustaflavone (3), agathisflavone (4), rhusflavone (5), rhusflavanone (6) and its hexaacetate (7), succedaneaflavanone (8) and its hexaacetate (9), cupressuflavone (10), neorhusflavanone (11), volkensiflavone (12) and its hexamethyl ether (13), spicataside (14) and its nonaacetate (15), morelloflavone (16) and its heptaacetate (17) and heptamethyl ether (18), GB-1a (19) and its hexamethyl ether (20) and 7"-O-beta-glucoside (21), and GB-2a (22), indicates that an ether linkage between two units of apigenin as seen in 1 is structurally required for significant cytotoxicity. Compounds 13 and 20 also demonstrated significant cytotoxicity.
    J Mol Graph Model. 2014 Apr;49:25-37.
    Discovery of potent inhibitor for matrix metalloproteinase-9 by pharmacophore based modeling and dynamics simulation studies.[Pubmed: 24473069]
    Matrix metalloproteinase-9 (MMP-9) is an attractive target for anticancer therapy.
    METHODS AND RESULTS:
    In the present study ligand based pharmacophore modeling was performed to elucidate the structural elements for a diverse class of MMP-9 inhibitors. The pharmacophore model was validated through G√ľner-Henry (GH) scoring method. The final pharmacophore model consisted of three hydrogen bond acceptors (HBA), and two ring aromatic regions (RA). This model was utilized to screen the natural compound database to seek novel compounds as MMP-9 inhibitors. The identified hits were validated using molecular docking and molecular dynamics simulation studies. Finally, one compound named Hinokiflavone from Juniperus communis had high binding free energy of -26.54kJ/mol compared with the known inhibitors of MMP-9. Cytotoxicity for Hinokiflavone was evaluated by MTT assay. Inhibition of MMP-9 in the presence of Hinokiflavone was detected by gelatin zymography and gelatinolytic inhibition assay.
    CONCLUSIONS:
    Results revealed that the natural compounds derived based on the developed pharmacophore model would be useful for further design and development of MMP-9 inhibitors.
    Morusinol

    Catalog No: CFN97086
    CAS No: 62949-93-3
    Price: $388/5mg
    Forsythoside E

    Catalog No: CFN90642
    CAS No: 93675-88-8
    Price: $188/10mg
    Galanthaminone

    Catalog No: CFN90742
    CAS No: 510-77-0
    Price: $318/10mg
    1-Methoxyphaseollidin

    Catalog No: CFN96878
    CAS No: 65428-13-9
    Price: $413/5mg
    Salvianolic acid Y

    Catalog No: CFN91004
    CAS No: 1638738-76-7
    Price: $333/5mg
    Naringin 4'-glucoside

    Catalog No: CFN95014
    CAS No: 17257-21-5
    Price: $338/5mg
    1-O-galloyl-6-O-cinnamoylglucose

    Catalog No: CFN95053
    CAS No: 115746-69-5
    Price: $338/5mg
    Bryonamide A

    Catalog No: CFN91056
    CAS No: 75268-14-3
    Price: $268/5mg
    3,7,25-Trihydroxycucurbita-5,23-dien-19-al

    Catalog No: CFN95150
    CAS No: 85372-65-2
    Price: $318/5mg
    Tigloylgomisin O

    Catalog No: CFN95237
    CAS No: 130855-74-2
    Price: $368/5mg