Harmine hydrochloride

Harmine hydrochloride
Product Name Harmine hydrochloride
CAS No.: 343-27-1
Catalog No.: CFN90341
Molecular Formula: C13H12N2O.HCl
Molecular Weight: 248.71 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Targets: Akt
Source: The herbs of Peganum harmala L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $40/20mg
Harmine hydrochloride has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Natural Product Res.&Deve.2022, 1001-6880.
  • Front Plant Sci.2020, 10:1705
  • Oncol Rep.2021, 46(2):166.
  • Molecules.2023, 28(5):2376.
  • Biomedicines.2024, 12(3):495.
  • Molecules.2022, 27(22):7997.
  • Food Chem X.2024, 24:101989.
  • J Ethnopharmacol.2024, 318:116863.
  • Appl. Sci.2021, 11(19),9343.
  • Preprints2022, 2022030063.
  • Harmalacidine

    Catalog No: CFN91937
    CAS No: 26579-69-1
    Price: Inquiry(manager@chemfaces.com)
    Harmol

    Catalog No: CFN91825
    CAS No: 487-03-6
    Price: $30/20mg
    Harmine hydrochloride

    Catalog No: CFN90341
    CAS No: 343-27-1
    Price: $40/20mg
    Harmine

    Catalog No: CFN98676
    CAS No: 442-51-3
    Price: $30/20mg
    Hydroxyevodiamine

    Catalog No: CFN90347
    CAS No: 1238-43-3
    Price: Inquiry(manager@chemfaces.com)
    Vincamine

    Catalog No: CFN90464
    CAS No: 1617-90-9
    Price: $40/20mg
    Vinpocetine

    Catalog No: CFN90467
    CAS No: 42971-09-5
    Price: $60/20mg
    7-Methoxy-beta-carboline-1-propionic acid

    Catalog No: CFN92013
    CAS No: 137756-13-9
    Price: Inquiry(manager@chemfaces.com)
    7-Hydroxy-beta-carboline-1-propionic acid

    Catalog No: CFN92206
    CAS No: 215934-15-9
    Price: Inquiry(manager@chemfaces.com)
    Ethyl beta-carboline-1-propionate

    Catalog No: CFN92746
    CAS No: 90686-24-1
    Price: Inquiry(manager@chemfaces.com)
    J Neurooncol. 2013 Mar;112(1):39-48.
    Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma.[Pubmed: 23392846]
    Harmine hydrochloride (Har-hc), a derivative from Harmine which is a natural extractive from plants, has been considered for treatment of kinds of cancers and cerebral diseases.
    METHODS AND RESULTS:
    In this study, we found that Harmine hydrochloride clearly decreased cell viability, induced apoptosis and inhibited Akt phosphorylation in glioblastoma cell lines. Moreover, Harmine hydrochloride had the ability to inhibit self-renewal and promote differentiation of glioblastoma stem like cells (GSLCs) accompanied by inhibition of Akt phosphorylation. Especially, we demonstrated that Harmine hydrochloride inhibited neurosphere formation of human primary GSLCs. In vivo test also confirmed Harmine hydrochloride decreased the tumorigenicity of GSLCs.
    CONCLUSIONS:
    Thus we conclude that Harmine hydrochloride has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation. Administration of Harmine hydrochloride may act as a new approach to glioblastoma treatment.
    Poricoic acid B

    Catalog No: CFN95050
    CAS No: 137551-39-4
    Price: $318/20mg
    Tigloylgomisin O

    Catalog No: CFN95237
    CAS No: 130855-74-2
    Price: $368/5mg
    Diosmin Impurity 8

    Catalog No: CFN95309
    CAS No: 28719-21-3
    Price: $318/10mg
    Peiioside B

    Catalog No: CFN95336
    CAS No: 1610618-91-1
    Price: $318/5mg
    Deoxy euphorbia factor L1

    Catalog No: CFN95340
    CAS No: 247099-01-0
    Price: $318/10mg
    Dipsacus saponin X

    Catalog No: CFN95359
    CAS No: 146100-01-8
    Price: $318/20mg
    5,6,7,3',4',5'-Hexamethoxyflavanone

    Catalog No: CFN95376
    CAS No: 74064-17-8
    Price: $318/10mg
    (2S)-5,7,3',4'-tetramethoxyflavanone

    Catalog No: CFN95406
    CAS No: 74628-43-6
    Price: $318/10mg
    Yakuchinone A

    Catalog No: CFN95555
    CAS No: 78954-23-1
    Price: $318/10mg
    Clinopodic acid E

    Catalog No: CFN95595
    CAS No: 159736-38-6
    Price: $318/5mg