Griffithazanone A
Reference standards.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Drug Chem Toxicol.2024, 1-10.
Phytomedicine.2015, 22(14):1262-8
J Hepatocell Carcinoma.2022, 9:327-341.
Phytomedicine.2019, 58:152893
Oxid Med Cell Longev2020, 12
Plants (Basel).2022, 11(16):2126.
Plant Foods Hum Nutr.2020, 10.1007
bioRxiv - Molecular Biology2023, 535548.
Molecular & Cellular Toxicology2022, 10.1007:s13273-022-00277-3
Front Cell Dev Biol.2020, 8:32.
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Fitoterapia. 2010 Oct;81(7):894-6.
A new cytotoxic 1-azaanthraquinone from the stems of Goniothalamus laoticus.[Pubmed:
20554005]
METHODS AND RESULTS:
A new 1-azaanthraquinone, named laoticuzanone A (1), and a synthetically known 3-methyl-1H-1-azaanthracene-2,9,10-trione (2), together with four known compounds, Griffithazanone A (3), methyl sinapate (4), methyl p-coumarate (5), and p-hydroxyphenylethyl p-coumarate (6) were isolated from the stems of Goniothalamus laoticus. Their structures were established on the basis of spectroscopic data as well as comparisons with the previous literature data.
CONCLUSIONS:
Compound 1 showed the highest cytotoxicity against KB and HeLa cells with IC(50) values of 0.68 and 0.50 μg/ml, respectively.
Chem Pharm Bull (Tokyo). 2006 Jul;54(7):1040-3.
New constituents from stems of Goniothalamus amuyon.[Pubmed:
16819228]
METHODS AND RESULTS:
Two new compounds, goniothalesacetate (1) and goniothalesdiol A (2) together with goniodiol-7-monoacetate, goniodiol-8-monoacetate, leiocarpin C, liriodenine, Griffithazanone A, 4-methyl-2,9,10-(2H)-1-azaanthracencetrione, velutinam and aristolactam BII were isolated and characterized from the stems of Goniothalamus amuyon. Structures of new compounds were determined by spectral analysis.
