Oxohydrastinine

J Med Plants Res.2011 Jan; 5.

Seven alkaloids and their antibacterial activity from Hypecoum erectum L.[Reference: WebLink]

METHODS AND RESULTS:
From the aerial part of Hypecoum erectum L., seven alkaloids, Protopine (1), Cryptopine (2), Allocryptopine (3), Hypecorinine (4), (-)-N-Methylcanadine (5), Oxohydrastinine (6) and N-Methylcorydaldine (7) were isolated. The structures of the seven compounds were established by 1 H-NMR, 13 C-NMR, DEPT and ESI-MS analyses. Compounds 2, 5 and 7 were obtained from this plant for the first time. The antibacterial activities were investigated against six bacteria (3 gram-positive and 3 gram-negative) by disc diffusion method followed by the minimal inhibitory concentration (MIC) which was determined using a two fold serial dilution assay for the compound which have inhibitory effect.
CONCLUSIONS:
In vitro antimicrobial activities assay indicated that some compounds showed promising activities. To the best of our knowledge, this is the first report on the antimicrobial properties of these alkaloids from this plant.

Phytochemistry.1999 Jan 26;50(2):339–343.

Five alkaloids from Hypecoum leptocarpum.[Reference: WebLink]

METHODS AND RESULTS:
Five new alkaloids, leptocarpinine, leptopine, leptopinine, leptopidine and leptopidinine were isolated, together with protopine, isohyperectine and Oxohydrastinine, from Hypecoum leptocarpum. The structures were elucidated by spectral evidence.