Ginsenoyne K

J Agric Food Chem. 2008 May 14;56(9):3024-7.

Cytotoxic phenylpropanoids from carrot.[Pubmed: 18422328]

Carrot is widely used as a foodstuff. The active components such as beta-carotene and panaxynol have been studied by many researchers.
METHODS AND RESULTS:
In this investigation of nonpolar active components from carrot, a new phenylpropanoid, epilaserine oxide ( 3), was isolated along with six known compounds, laserine ( 1), 2-epilaserine ( 2), panaxynol ( 4), Ginsenoyne K ( 5), (8 E)-1,8-heptadecadiene-4,6-diyne-3,10-diol ( 6), and vaginatin ( 7). Their structures were deduced on the basis of spectroscopic methods. Significant cytotoxicity of 2-epilaserine against HL-60 cells was observed, which implied that phenylpropanoids were cytotoxic compounds in carrot.
CONCLUSIONS:
Laserine and 2-epilaserine in carrots from diverse locations in China were quantified by HPLC.

Natural Product Sciences, 2008 , 14 (3) :177-181.

Polyacetylenes from the tissue cultured adventitious roots of Panax ginseng C.A. meyer[Reference: WebLink]

METHODS AND RESULTS:
Five polyacetylenes, Ginsenoyne K (1), (Z)-1-methoxyheptadeca-9-en-4,6-diyne-3-one (2), panaxydol (3), panaxydiol (4), and (E)-heptadeca-8-en-4,6-diyne-3,10-diol (5) were isolated from the adventitious roots of Panax ginseng and their chemical structures were elucidated by interpretation of spectroscopic data. Among the isolated compounds, compounds 2 and 5 were reported for the first time as a natural product.
CONCLUSIONS:
Ginsenoyne K (1) showed dose-dependent inhibitory effect on dopa oxidase activity of tyrosinase.