Gelsempervine A
Gelsempervine A is a natural product from Gelsemium elegans.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Symposium on the chemistry of natural products, 2006 (48) :319-324.
New Indole Alkaloids from Gelsemium Plants and their Cytotoxic Activity on Tumor Cells[Reference:
WebLink]
Gelseiridone (10) is a new type of alkaloid having a nitrogen-carbon linkage between a gelsenicine-type monoterpenoid indole alkaloid that possesses an α,β-unsaturated ketone residue as well as the N_b-C20 seco-form and a monoterpene unit having an iridoid skeleton.
METHODS AND RESULTS:
Five new sarpagine-type alkaloids, Gelsempervine A (23), gelsempervine B (24), gelsempervine C (25), and gelsempervine D (26), and 19Z-16-epi-voacarpine (27), and one yohimbane-type alkaloid, sempervilam (29) were isolated from G. sempervirens.
CONCLUSIONS:
Spectroscopic data suggest that 23 existed as a C/D ring-opening structure with the keto-amine form (A) in such aprotic solvents as CH3CN, and as a transannular structure with the zwitterionic form (B) in such protic solvents as CH3OH.
