Spegatrine
Spegatrine is a natural product from Rauvolfia verticillata.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
J Adv Res.2019, 17:85-94
PLoS One.2021, 16(9):e0257243.
Environ Toxicol.2020, doi: 10.1002
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Cell Chem Biol.2019, 26(1):27-34
Food Chem.2021, 337:128023.
Int J Mol Sci.2021, 22(11):5503.
Sci Rep.2021, 11(1):21038.
Phytochem Anal.2021, 32(6):970-981.
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Phytochemistry. 2015 Jan;109:84-95.
Indole alkaloids from the Marquesan plant Rauvolfia nukuhivensis and their effects on ion channels.[Pubmed:
25468537]
In addition to the already reported nukuhivensiums 1 and 2, 11 indole alkaloids were isolated from the bark of the plant Rauvolfia nukuhivensis, growing in the Marquesas archipelago.
METHODS AND RESULTS:
The known sandwicine (3), isosandwicine (4), Spegatrine (8), lochneram (9), flavopereirine (13) have been found in this plant together with the norsandwicine (5), isonorsandwicine (6), Nb-methylisosandwicine (7), 10-methoxypanarine (10), nortueiaoine (11), tueiaoine (12). The structure elucidation was performed on the basis of a deep exploration of the NMR and HRESIMS data as well as comparison with literature data for similar compounds.
CONCLUSIONS:
Norsandwicine, 10-methoxypanarine, tueiaoine, and more importantly nukuhivensiums, were shown to significantly induce a reduction of IKr amplitude (HERG current). Molecular modelling through docking was performed in order to illustrate this result.
