Gardenine
Gardenin has regulatory effect on the gene expression in rats with focal cerebral ischemia.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Journal of Mushroom2023, 21(4):215-221.
Theranostics.2023, 13(9):3103-3116.
Cancers (Basel).2023, 15(1):293.
Sci Rep. 2024, 14(1):70.
Int J Cosmet Sci.2023, 45(2):155-165.
J Pharm Biomed Anal.2024, 247:116257.
Processes2021, 9(1), 153.
Applied Biological Chemistry2021, 64(4)
Antioxidants (Basel).2022, 11(12):2327.
Nat Commun.2021, 12(1):681.
Related and Featured Products
Planta Med. 1991 Dec;57(6):536-42.
Formation of nitrogen-containing metabolites from geniposide and gardenoside by human intestinal bacteria.[Pubmed:
1818345]
METHODS AND RESULTS:
During the course of our studies on the metabolism of iridoid glycosides by human intestinal bacteria, we found that geniposide (1) and gardenoside (4) were transformed to new nitrogen-containing compounds, genipinine (3) and Gardenine (6), respectively, along with the known aglycones. Although the amounts of new metabolites were somewhat lower than those of the aglycones, they were quantitatively analyzed by means of liquid chromatography/mass spectrometry (LC/MS).
CONCLUSIONS:
Of 25 strains of human intestinal bacteria, Peptostreptococcus anaerobius, Klebsiella pneumoniae, Fusobacterium nucleatum, and Bacteroides fragilis ssp. thetaotus produced appreciable amounts of 3, while a bacterial mixture of human feces produced 10 times or more higher amounts of 3, as compared to the individual strains.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 Jan;25(1):42-4.
Effect of gardenin on gene expression profile in brain of rats with focal cerebral ischemia[Pubmed:
15719750]
Total RNAs were isolated from rats with FCI and those treated with gardenin.
METHODS AND RESULTS:
The mRNAs were reversely transcribed to cDNA with incorporation of fluorescent Cy5- or Cy3-dUTP to prepare hybridization probes. The PCR products of 4096 genes were spotted on the chip after a serial treatment. The mixed probes were hybridized to the cDNA microarray. Axon Genepix 4000B and GenePixPro 3.0 software were used to scan and analyze the fluorescent signals. In the group treated with gardenin, there were 70 genes had expression profiles different to that in the model group in the focal cerebral ischemic brain tissue, in which 68 were up-regulated and 2 down-regulated.
CONCLUSIONS:
Gardenin has regulatory effect on the gene expression in rats with focal cerebral ischemia, which elucidates part of the pharmacologic mechanism of Qingkailing in molecular level.
