Furomollugin

Furomollugin
Product Name Furomollugin
CAS No.: 61658-41-1
Catalog No.: CFN97055
Molecular Formula: C14H10O4
Molecular Weight: 242.2 g/mol
Purity: >=98%
Type of Compound: Naphthols
Physical Desc.: Powder
Targets: Antifection
Source: The roots of Rubia cordifolia L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Furomollugin has antiviral activity, it can strongly suppress the secretion of hepatitis B surface antigen (HBsAg), with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    J Nat Prod. 1996 Mar;59(3):330-3.
    Inhibition of hepatitis B surface antigen secretion on human hepatoma cells. Components from Rubia cordifolia.[Pubmed: 8882438]

    METHODS AND RESULTS:
    The antiviral activity in the roots of Rubia cordifolia was examined, and three naphthohydroquinones, Furomollugin (1), mollugin (2), and rubilactone (3), were isolated from it. Compounds 1 and 2 strongly suppressed the secretion of hepatitis B surface antigen (HBsAg), both with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells while having little effect on the viability of the cells.
    CONCLUSIONS:
    Evaluation of structurally related derivatives of 1 and 2 revealed that a 6-hydroxy group and a pyran or furan ring contribute to this suppressive effect.
    Nat Prod Commun. 2015 Jun;10(6):1025-6.
    Phthalide Anions in Organic Synthesis. A Direct Total Synthesis of Furomollugin.[Pubmed: 26197542]

    METHODS AND RESULTS:
    Furomollugin was synthesized in three steps from commercially available starting materials using phthalide annulation chemistry.
    Org Biomol Chem. 2013 Sep 28;11(36):6097-107.
    A novel and efficient synthesis of diverse dihydronaphtho[1,2-b]furans using the ceric ammonium nitrate-catalyzed formal [3 + 2] cycloaddition of 1,4-naphthoquinones to olefins and its application to furomollugin.[Pubmed: 23963248]

    METHODS AND RESULTS:
    A novel approach was developed for the synthesis of diverse dihydronaphtho[1,2-b]furans from 1,4-naphthoquinones and olefins in the presence of ceric ammonium nitrate. This reaction provides a rapid route for the synthesis of a variety of dihydronaphtho[1,2-b]furans and naphtho[1,2-b]furans bearing different substituents.
    CONCLUSIONS:
    This methodology was also used to synthesize the biologically important natural product Furomollugin in only 2 steps.
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