Fulvine
Fulvine is a hepatotoxic pyrrolizidine alkaloid. An aqueous solution of Fulvine can produce an acute pancreatopathy with interstitial oedema and secondary hypoxic dystrophy of the acinar cells, when administered at doses of 10 and 20 mg/kg body weight.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Toxicol Lett. 1984 May;21(2):185-9.
Activation of monocrotaline, fulvine and their derivatives to toxic pyrroles by some thiols.[Pubmed:
6426098]
METHODS AND RESULTS:
Arylthiols - in contrast to n-alkylthiols, cysteine and reduced glutathione--dehydrogenated monocrotaline, Fulvine, their N-oxides and retronecine to activated pyrrole derivatives.
CONCLUSIONS:
All thiols used failed to dehydrogenate N-methyl derivatives of monocrotaline and Fulvine.
Exp Pathol (Jena). 1976;12(6):329-35.
Cytotoxicity of the pyrrolizidine alkaloid fulvine to pancreatic acinar cells in the rat. Light microscopic, histochemical and ultrastructural studies.[Pubmed:
1010013]
Veno-occlusive disease of the liver is caused by the hepatotoxic pyrrolizidine alkaloid Fulvine which is found in the plant Crotolaria fulva.
METHODS AND RESULTS:
Histological, histochemical and electronmicroscopic studies carried out in Wistar rats showed that an aqueous solution of Fulvine produced an acute pancreatopathy with interstitial oedema and secondary hypoxic dystrophy of the acinar cells, when administered at doses of 10 and 20 mg/kg body weight.
