Eupalinolide I

Eupalinolide I
Product Name Eupalinolide I
CAS No.: 1402067-84-8
Catalog No.: CFN89073
Molecular Formula: C24H30O9
Molecular Weight: 462.49 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Oil
Targets: STAT
Source: The aerial plants of Eupatorium lindleyanum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Eupalinolide I is a natural product from Eupatorium lindleyanum.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Ginseng Res.2020, 44(4):611-618.
  • Appl. Sci.2022, 12(17), 8646.
  • J Food Sci Technol.2019, 56(5):2712-2720
  • HortTechnology2016, 26(6):816-819
  • Herbal Formula Science2024, 32(3):203-221
  • Front Plant Sci.2021, 12:673337.
  • Int J Mol Sci.2023, 25(1):162.
  • Turkish Journal of Pharmaceutical Sciences2022, DOI: 10.4274
  • Evidence-based Compl.&Alternative Med.2023, 5417813
  • LWT-Food Sci Technol2020, 109163
  • Eupahualin C

    Catalog No: CFN96931
    CAS No: 108525-39-9
    Price: Inquiry(manager@chemfaces.com)
    Eupalinolide I

    Catalog No: CFN89073
    CAS No: 1402067-84-8
    Price: Inquiry(manager@chemfaces.com)
    Deacetylorientalide

    Catalog No: CFN89008
    CAS No: 1258517-59-7
    Price: Inquiry(manager@chemfaces.com)
    9-O-Ethyldeacetylorientalide

    Catalog No: CFN89009
    CAS No: 1258517-60-0
    Price: Inquiry(manager@chemfaces.com)
    Orientalide

    Catalog No: CFN95136
    CAS No: 72704-05-3
    Price: $368/5mg
    13-Acetoxy-3beta-hydroxygermacra-1(10)E,4E,7(11)-trien-12,6alpha-olide

    Catalog No: CFN89013
    CAS No: 126829-66-1
    Price: Inquiry(manager@chemfaces.com)
    Vernolide B

    Catalog No: CFN96456
    CAS No: 618860-58-5
    Price: Inquiry(manager@chemfaces.com)
    8beta-Tigloyloxycostunolide

    Catalog No: CFN96813
    CAS No: 96850-21-4
    Price: Inquiry(manager@chemfaces.com)
    Eupaglehnin C

    Catalog No: CFN96816
    CAS No: 476630-49-6
    Price: Inquiry(manager@chemfaces.com)
    Eupatoriopicrin

    Catalog No: CFN96814
    CAS No: 6856-01-5
    Price: Inquiry(manager@chemfaces.com)
    Nat Prod Res. 2017 Oct 31:1-9.
    Precise discovery of a STAT3 inhibitor from Eupatorium lindleyanum and evaluation of its activity of anti-triple-negative breast cancer.[Pubmed: 29086600]
    Michael reaction acceptors (MRAs) are a class of active compounds. There is a great prospect to screen STAT3 inhibitors from Eupatorium lindleyanum, furthermore, to discover lead compounds for anti-triple-negative breast cancer (TNBC).
    METHODS AND RESULTS:
    In this study, glutathione (GSH) was employed, and a UPLC-MS screening method was developed to discover MRAs. We screened MRAs which can inhibit STAT3 using a STAT3-dependent reporter system. Six sesquiterpene lactones, including a new compound Eupalinolide O (1), together with five known compounds, Eupalinolide I (2), Eupalinolide K (3), Eupalinolide H (4), Eupalinolide J (5) and Eupalinolide G (6) were isolated. Eupalinolide J was identified as MRA that decreased luciferase activity of STAT3.
    CONCLUSIONS:
    Preliminary activity assessment showed that Eupalinolide J could inhibit the viability of TNBC cell lines. We demonstrated that Eupalinolide J, which is a natural typical MRA, has a notable inhibition of STAT3 activity and a potential cytotoxic activity against TNBC cell lines.
    3''-Galloylquercitrin

    Catalog No: CFN95048
    CAS No: 503446-90-0
    Price: $368/5mg
    Cassiaside C

    Catalog No: CFN95120
    CAS No: 119170-52-4
    Price: $318/10mg
    Cassiaglycoside II

    Catalog No: CFN95130
    CAS No: 2241081-56-9
    Price: $368/5mg
    ent-16beta,17-dihydroxy-9(11)-kauren-19-oic acid

    Catalog No: CFN95172
    CAS No: 55483-24-4
    Price: $318/10mg
    11-Deoxyisomogroside V

    Catalog No: CFN95288
    CAS No: 1628293-32-2
    Price: $368/10mg
    Euphorbia factor L22

    Catalog No: CFN95338
    CAS No: 1613700-09-6
    Price: $413/5mg
    Annphenone

    Catalog No: CFN95426
    CAS No: 61775-18-6
    Price: $318/10mg
    Oxytroflavoside E

    Catalog No: CFN95464
    CAS No: 1391144-84-5
    Price: $318/5mg
    Catechin 7-O-beta-D-glucopyranoside

    Catalog No: CFN95524
    CAS No: 65597-47-9
    Price: $338/20mg
    Methyl ganoderenate F

    Catalog No: CFN95573
    CAS No: N/A
    Price: $413/5mg