Eupaglehnin C
Eupaglehnin C shows cytotoxic (2.19 mg/ml) against HeLa-S3.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chem Pharm Bull (Tokyo). 2002 Sep;50(9):1250-4.
Seven germacranolides, eupaglehnins A, B, C, D, E, and F, and 2alpha-acetoxyepitulipinolide from Eupatorium glehni.[Reference:
WebLink]
We have been interested in biologically active terpenoids from Compositae9—14) and collected E. glehni6—8) in Tokushima and Hokkaido, Japan.
METHODS AND RESULTS:
From the ethyl acetate-soluble fraction of the methanol extract, we have found four new germacranolides with unsaturated esters at the 8-position, eupaglehnin A, eupaglehnin B, Eupaglehnin C, and eupaglehnin D, and two new chlorine atom-containing germacranolides, eupaglehnin E (5) and eupaglehnin F (6),13) as well as 2a-acetoxyepitulipinolide (7) for the first time from natural sources. In our attempt to find cytotoxic compounds, eupatoriopicrin (8) 24—29) was the most effective (1.40 mg/ml), followed by Eupaglehnin C (3) (2.19 mg/ml) against HeLa-S3. However, eupaglehnin E (5) and eupaglehnin F (6) did not show cytotoxic activity, which is understandable because they had no exomethylene group.
CONCLUSIONS:
In preliminary experiments, eupatoriopicrin (8) 24—26) also showed apoptotic activity against Ha-60 cell lines, the details of which will be published in due course.
