Ethyl 2,4,6-trihydroxybenzoate
Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells. It suppresses cellular cholesterol accumulation in a dose-dependent manner and induces the transcriptional activation of LXR-α/-β-responsive genes.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Asian Journal of Chemistry, 2005 , 17 (4) :2353-2358.
Antimicrobial guided phytochemical evaluation of the pods of Caesalpinia pulcherrima[Reference:
WebLink]
METHODS AND RESULTS:
The alcoholic extract of the pods of the plant C. pulcherrima afforded five antimicrobial compounds: four homoisoflavonids (4-O-methylsappanol, protosappanin A, brazilin and caesalpin J) and Ethyl 2,4,6-trihydroxybenzoate. The structures of the compounds were established by means of NMR spectroscopic analysis. Antimicrobial activity of the compounds was evaluated against pathogenic gram -ve and gram +ve bacteria and fungi.
Bioorg Med Chem Lett. 2012 Jun 15;22(12):4094-9.
Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.[Pubmed:
22579484 ]
METHODS AND RESULTS:
The present study reports a novel liver X receptor (LXR) activator, Ethyl 2,4,6-trihydroxybenzoate (ETB), isolated from Celtis biondii. In macrophages, hepatocytes, and intestinal cells, Ethyl 2,4,6-trihydroxybenzoate suppressed cellular cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes. Notably, Ethyl 2,4,6-trihydroxybenzoate did not induce lipogenic gene expression or cellular triglyceride accumulation in hepatocytes.
CONCLUSIONS:
These results suggest that Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells.
