Eriodictyol chalcone
Eriodictyol chalcone has anti-plasmodial effects on P. falciparum growth.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Food Funct.2021, 12(4):1469-1481.
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Plant Science, 1997, 122(2):125-131.
Halbwirth H , Wimmer G , Wurst F , et al. Enzymatic glucosylation of 4-deoxyaurones and 6′-deoxychalcones with enzyme extracts of Coreopsis grandiflora, Nutt. I.[Reference:
WebLink]
METHODS AND RESULTS:
The orange-yellow colouration of Coreopsis grandiflora is mainly provided by the 6′-deoxychalcone butein and its 4′-glucoside respectively, as well as the corresponding 4-deoxyaurones sulfuretin and leptosidin (7-methoxysulfuretin) and their 6-glucosides. Incubation of butein or sulfuretin with enzyme preparations from petals of Coreopsis grandiflora in the presence of uridine 5′-diphosphoglucose led in each case to the formation of one single product, which was identified as butein 4′-glucoside and sulfuretin 6-glucoside, respectively. The 6′-deoxychalcone isoliquiritigenin was a poor substrate. Glucosylation of hydroxyl groups in other positions was not observed. Naringenin chalcone and Eriodictyol chalcone were not accepted as substrates. The glucosylation reaction of butein and sulfuretin exhibited an optimum at pH 8.0 and 7.0, respectively. Bivalent ions like Mg2+ and Ca2+ stimulated only slightly, whereas the addition of Cu2+, Zn2+, N-ethylmaleimide and p- hydroxymercuribenzoate led to a total loss of enzyme activity. The apparent Km values for butein and sulfuretin were 146 and 44 μM, respectively.
CONCLUSIONS:
The specific enzyme activity increased slowly during bud and flower development and declined in the later stages. The highest specific activity was observed in open flowers with 30 mm diameter. The rates of the glucosylation reaction with butein and sulfuretin had similar patterns.
