Eriodictyol-7-O-glucoside
Eriodictyol-7-O-glucoside and epicatechin appears to be responsible for the antioxidant activity of pistachio skin.Eriodictyol-7-O-glucoside has protective effect on cisplatin-induced toxicity was investigated in a human renal mesangial cell line, HRMC; it also can activate Nrf2/ARE signaling, directly associated with its neuroprotection against oxidative stress-induced ischemic; suggests that targeting the Nrf2/ARE pathway may be a promising approach for therapeutic intervention in stroke.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Food Chem Toxicol. 2012 Jun;50(6):1927-32.
Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity.[Pubmed:
22465804]
Eriodictyol-7-O-glucoside, a flavonoid isolated from Dracocephalum rupestre, is among the most potent free radical scavenger.
METHODS AND RESULTS:
In the present study, we identified Eriodictyol-7-O-glucoside as a novel nuclear factor E2-related factor 2 (Nrf2) activator using a high-throughput cellular screening method. This compound activated Nrf2 signaling pathway and was able to stabilize Nrf2 by delaying Nrf2 degradation, resulting in accumulation of Nrf2 protein and activation of the Nrf2-dependent protective response. Recent studies have suggested that activation of Nrf2 pathway would confer protection against cisplatin-induced toxicity. The protective role of Eriodictyol-7-O-glucoside in cisplatin-induced toxicity was investigated in a human renal mesangial cell line, HRMC. Cotreatment of HRMC cells with Eriodictyol-7-O-glucoside significantly improved cell survival under cisplatin exposure.
CONCLUSIONS:
These findings demonstrated the feasibility of using natural compounds targeting Nrf2 as a therapeutic approach to subvert the side effects of cisplatin in normal cells.
Biochimie. 2010 Sep;92(9):1115-22.
Antioxidant activity and phenolic profile of pistachio (Pistacia vera L., variety Bronte) seeds and skins.[Pubmed:
20388531]
METHODS AND RESULTS:
By HPLC analysis, gallic acid, catechin, Eriodictyol-7-O-glucoside, naringenin-7-O-neohesperidoside, quercetin-3-O-rutinoside and eriodictyol were found both in pistachio seeds than in skins; furthermore, genistein-7-O-glucoside, genistein, daidzein and apigenin appeared to be present only in pistachio seeds, while epicatechin, quercetin, naringenin, luteolin, kaempferol, cyanidin-3-O-galactoside and cyanidin-3-O-glucoside are contained only in pistachio skins. The antioxidant activity of pistachio seeds and skins were determined by means of four different assays (DPPH assay, Folin-Ciocalteau colorimetric method and TEAC assay, SOD-mimetic assay). As expected on the basis of the chemical analyses, pistachio skins have shown to possess a better activity with respect to seeds in all tests. The excellent antioxidant activity of pistachio skins can be explained by its higher content of antioxidant phenolic compounds.
CONCLUSIONS:
By HPLC-TLC analysis, gallic acid, catechin, cyanidin-3-O-galactoside, Eriodictyol-7-O-glucoside and epicatechin appeared to be responsible for the antioxidant activity of pistachio skin, together with other unidentified compounds.
Toxicol Appl Pharmacol. 2013 Dec 15;273(3):672-9.
Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury.[Pubmed:
24466583]
The aim of the present study was to determine whether Eriodictyol-7-O-glucoside (E7G), a novel Nrf2 activator, can protect against cerebral ischemic injury and to understand the role of the Nrf2/ARE pathway in neuroprotection.
METHODS AND RESULTS:
In primary cultured astrocytes, Eriodictyol-7-O-glucoside increased the nuclear localization of Nrf2 and induced the expression of the Nrf2/ARE-dependent genes. Exposure of astrocytes to Eriodictyol-7-O-glucoside provided protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. The protective effect of Eriodictyol-7-O-glucoside was abolished by RNA interference-mediated knockdown of Nrf2 expression. In vivo administration of Eriodictyol-7-O-glucoside in a rat model of focal cerebral ischemia significantly reduced the amount of brain damage and ameliorated neurological deficits.
CONCLUSIONS:
These data demonstrate that activation of Nrf2/ARE signaling by Eriodictyol-7-O-glucoside is directly associated with its neuroprotection against oxidative stress-induced ischemic injury and suggest that targeting the Nrf2/ARE pathway may be a promising approach for therapeutic intervention in stroke.
