Epiaschantin

Epiaschantin
Product Name Epiaschantin
CAS No.: 41689-50-3
Catalog No.: CFN96901
Molecular Formula: C22H24O7
Molecular Weight: 400.42 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The trunk barks of Hernandia nymphaeifolia.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $368/5mg
(+)-Epiaschantin shows marginal cancer cell line inhibitory activities. It also has anti-platelet aggregation activity.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Nat Prod Sci.2016 Jun;22(2)
  • Lab On a Chip21 Feb 2018;
  • Journal of Agricultural Science2015 Sep 15
  • Ajchem JournalJAN. 2014
  • Molecules. 2017 Jun 2;
  • Planta Med 2016 Apr 28.
  • Virulence.2018 Jan 1;
  • Evidence-Based Complementary & Alternative Med.2017
  • Scientific Reports2015 August 26
  • ScientificWorldJournal. 2014 Feb 9.
  • Epimagnolin A

    Catalog No: CFN90949
    CAS No: 41689-51-4
    Price: $268/10mg
    Epiaschantin

    Catalog No: CFN96901
    CAS No: 41689-50-3
    Price: $368/5mg
    Sesartemin

    Catalog No: CFN97907
    CAS No: 77394-27-5
    Price: Inquiry(manager@chemfaces.com)
    Episesartemin A

    Catalog No: CFN96936
    CAS No: 77449-31-1
    Price: Inquiry(manager@chemfaces.com)
    1-Hydroxypinoresinol 1-O-glucoside

    Catalog No: CFN96713
    CAS No: 81495-71-8
    Price: Inquiry(manager@chemfaces.com)
    Fraxiresinol 1-O-glucoside

    Catalog No: CFN97460
    CAS No: 89199-94-0
    Price: Inquiry(manager@chemfaces.com)
    Prenylpiperitol

    Catalog No: CFN99668
    CAS No: 157659-20-6
    Price: Inquiry(manager@chemfaces.com)
    Sesamin

    Catalog No: CFN97034
    CAS No: 607-80-7
    Price: $40/20mg
    Paulownin

    Catalog No: CFN99394
    CAS No: 13040-46-5
    Price: Inquiry(manager@chemfaces.com)
    Sesamolin

    Catalog No: CFN99799
    CAS No: 526-07-8
    Price: $238/20mg
    J Nat Prod. 2004 Feb;67(2):214-20.
    Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives).[Pubmed: 14987061 ]
    Bioassay (P388 lymphocytic leukemia cell line and human tumor cell lines)-guided separation of the extracts prepared from the tropical and coastal trees Hernandia peltata (Malaysia) and Hernandianymphaeifolia (Republic of Maldives) led to the isolation of a new lignan designated as hernanol (1) and 12 previously known lignans: (-)-deoxypodophyllotoxin (2), deoxypicropodophyllin (3), (+)-Epiaschantin (4), (+)-epieudesmin (5), praderin (6), 5'-methoxyyatein (7), podorhizol (8), deoxypodorhizone (9), bursehernin (10), kusunokinol (11), clusin (12), and (-)-maculatin (13). The oxidative cyclization (with VOF(3)) of lignans 8, 9, and 10 resulted in a new and unusual benzopyran (14), isostegane (15), and a new dibenzocyclooctadiene lactone (16), respectively.
    METHODS AND RESULTS:
    The structure and relative stereochemistry of hernanol (1) and lignans 3, 7, 8, 9, 10, 11, and 12 were determined by 1D and 2DNMR and HRMS analyses. The structures and absolute stereochemistry of structures 2, 4, 5, 6, 13, 14, 15, and 16 were unequivocally determined by single-crystal X-ray diffraction analyses. Evaluation against the murine P388 lymphocytic leukemia cell line and human tumor cell lines showed podophyllotoxin derivatives 2 and 3 to be strong cancer cell line growth inhibitors and substances 4, 5, 8, and 15 to have marginal cancer cell line inhibitory activities.
    CONCLUSIONS:
    Seven of the lignans and one of the synthetic modifications (14) inhibited growth of the pathogenic bacterium Neisseria gonorrhoeae.
    Planta Med. 1996 Dec;62(6):528-33.
    New dimeric aporphine alkaloids and cytotoxic constituents of Hernandia nymphaeifolia.[Pubmed: 9000885]
    Three minor new dimeric aporphine alkaloids, oviisocorydine (1), ovihernangerine (2), and oxohernandaline (3), along with four known alkaloids, (+)-hernandaline, (+)-thallcarpine, (+)-N-methylovigerine, and N-methylcorydaldine, and five known lignans, (+)-epimagnolin, (+)-Epiaschantin, (+)-epiyangambin, (-)-deoxypodophyllotoxin, and (-)-yatein, have been additionally isolated from the trunk bark of Hernandia nymphaeifolia.
    METHODS AND RESULTS:
    The structures of these compounds were elucidated by spectroscopic methods. Among forty-four isolates obtained till now, nine compounds, hernandonine (4), hernanymphine (5), demethylsonodione (6), (+)-ovigerine (7), (+)-N-methylovigerine (8), N-formyldehydroovigerine (9), 4-methoxyoxohernandaline (10), (-)-deoxypodophyllotoxin (11), and (-)-yatein (12) showed significant cytotoxic activities (ED50 values < 1 microgram/ml) against P-388, KB16, A549, and HT-29 cell lines.
    Planta Med. 2000 Apr;66(3):251-6.
    Anti-platelet aggregation alkaloids and lignans from Hernandia nymphaeifolia.[Pubmed: 10821052]
    A new aporphine, N-(N-methylcarbamoyl)-O-methyl-bulbocapnine (1), together with seven known compounds, (-)-5'-methoxypodorhizol (2), a mixture of beta-sitosterone (3) and stigmasta-4,22-dien-3-one (4), a mixture of 3 beta-hydroxystigmast-5-en-7-one (5) and 3 beta-hydroxystigmasta-5,22-dien-7-one (6), and a mixture of 6 alpha-hydroxystigmast-4-en-3-one (7) and 6 alpha-hydroxystigmasta-4,22-dien-3-one (8), were isolated in continuing studies on the trunk bark of Formosan Hernandia nymphaeifolia.
    METHODS AND RESULTS:
    The structures of these compounds were determined through spectral analyses. In addition, the previously reported six alkaloids, laurotetanine, oxohernagine, thalicarpine, reticuline, (+)-vateamine-2'-beta-N-oxide, (+)-hernandaline and six lignans, (+)-Epiaschantin, (+)-epimagnolin, (+)-epiyangambin, (-)-hernone, (-)-yatein, (-)-deoxypodophyllotoxin were demonstrated to have anti-platelet aggregation activity.
    Bavachinin

    Catalog No: CFN98006
    CAS No: 19879-30-2
    Price: $128/20mg
    Arteannuin B

    Catalog No: CFN98807
    CAS No: 50906-56-4
    Price: $228/20mg
    Kushenol C

    Catalog No: CFN92391
    CAS No: 99119-73-0
    Price: $468/10mg
    2''-O-Rhamnosylicariside II

    Catalog No: CFN92551
    CAS No: 135293-13-9
    Price: $388/10mg
    7,2',4'-Trihydroxy-5-methoxy-3-phenylcoumarin

    Catalog No: CFN96001
    CAS No: 1092952-62-9
    Price: $413/5mg
    Galanthaminone

    Catalog No: CFN90742
    CAS No: 510-77-0
    Price: $318/10mg
    Magnolignan A

    Catalog No: CFN96188
    CAS No: 93673-81-5
    Price: $388/5mg
    7-Neohesperidosides

    Catalog No: CFN95018
    CAS No: 28383-41-7
    Price: $288/5mg
    Ganoderic acid L

    Catalog No: CFN95022
    CAS No: 102607-24-9
    Price: $413/5mg
    Fargesol

    Catalog No: CFN95027
    CAS No: 128855-64-1
    Price: $318/20mg