Drimenol
Drimenol shows antifungal activity, it is able to affect Botrytis cinerea growth with the EC50 value of 80 ppm. Drimendiol also shows quorum sensing inhibition activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Pestic Biochem Physiol. 2017 Sep;141:50-56.
Effect of drimenol and synthetic derivatives on growth and germination of Botrytis cinerea: Evaluation of possible mechanism of action.[Pubmed:
28911740]
The aim of this study was to determine the antifungal activity of Drimenol (1) and its synthetic derivatives, nordrimenone (2), drimenyl acetate (3), and drimenyl-epoxy-acetate (4), and to establish a possible mechanism of action for Drimenol.
METHODS AND RESULTS:
For that, the effect of each compound on mycelial growth of Botrytis cinerea was assessed. Our results showed that compounds 1, 2, 3 and 4 are able to affect Botrytis cinerea growth with EC50 values of 80, 92, 80 and 314ppm, respectively.
CONCLUSIONS:
These values suggest that the activity of these compounds is mainly determined by presence of the double bond between carbons 7 and 8 of the drimane ring. In addition, germination of B. cinerea in presence of 40 and 80ppm of Drimenol is reduced almost to a half of the control value. Finally, in order to elucidate a possible mechanism by which Drimenol is affecting B. cinerea, the determination of membrane integrity, reactive oxygen species production and gene expression studies of specific genes were performed.
Nat Prod Commun. 2013 Feb;8(2):147-8.
Drimendiol, a drimane sesquiterpene with quorum sensing inhibition activity.[Pubmed:
23513712]
Quorum sensing (QS) is a regulatory mechanism that enables bacteria to make collective decisions such as an increase in virulence factors and biofilm production. Inhibitors of QS are important research tools in the discovery of new potential anti-bacterial agents.
METHODS AND RESULTS:
Polygodial, Drimenol and drimendiol are drimane sesquiterpenoids isolated from Drimys winteri, a Chilean native tree.
Their QS activity, when tested on Chromobacterium violaceum ATCC 12472, showed that drimendiol is an inhibitor of QS, decreasing violaceine production in C violaceum and decreasing biofilm formation of Pseudomonas syringae strains.
CONCLUSIONS:
Consequently it increased the biocide effects of CuSO4 on biofilms of P. syringae.
