Methyl isodrimeninol | CAS:442851-27-6

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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Sci Rep.2018, 8:15059

J Chromatogr B Analyt Technol Biomed Life Sci.2021, 1187:123012.

Evid Based Complement Alternat Med.2016, 2016:1739760

Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112

Yakugaku Zasshi.2018, 138(4):571-579

Br J Pharmacol.2018, 175(6):902-923

Molecules2022, 27(12):3903.

Vietnam Journal of Food Control.2022, 5(2): 115-128.

Nutrients.2020, 12(3):595.

Biochem Biophys Res Commun.2020, 522(1):40-46

Bioorganic & Medicinal Chemistry Letters,2002,12(3): 477–482.

Protective effects of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action[Reference: WebLink]

The methanolic extract from the leaves of Tasmannia lanceolata was found to potently inhibit ethanol-induced gastric lesions in rats.
METHODS AND RESULTS:
Through bioassay-guided separation, three known sesquiterpenes, polygodial, polygodial 12α-acetal, and polygodial 12β-acetal, and a new sesquiterpene, Methyl isodrimeninol, were isolated as the active constituents. Among them, polygodial showed very potent gastroprotective effects (ED50=0.028 mg/kg, po). From the gastroprotective effects of various reduction and oxidation derivatives of polygodial, the dialdehyde or diacetal structure was found to be essential for the strong activity.
CONCLUSIONS:
Since the gastroprotection of polygodial was attenuated by pretreatment with indomethacin, N-ethylmaleimide, NG-nitro-l-arginine methyl ester and ruthenium red, endogenous prostaglandins, sulfhydryl compounds, nitric oxide and vanilloid receptors may be involved in the protective activity.

Product Name	Methyl isodrimeninol
CAS No.:	442851-27-6
Catalog No.:	CFN98677
Molecular Formula:	C₁₆H₂₆O₂
Molecular Weight:	250.4 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Oil
Source:	The herbs of Polygonum flaccidum Meissn.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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